Characterization of concatemeric plasmids of Neisseria gonorrhoeae.

Infection and Immunity
S R JohnsonW DeWitt

Abstract

Three strains of Neisseria gonorrhoeae carried novel plasmids of 7.8 megadaltons (mdal) molecular mass in addition to plasmids previously observed in this organism. The presence of the 7.8-mdal plasmids was not accompanied by any distinguishable phenotype in the strain possessing them. Analysis of plasmid DNA with restriction endonucleases showed that these plasmids were composed of three directly repeated copies of a 2.6-mdal cryptic plasmid frequently found in N. gonorrhoeae. In addition, the 7.8-mdal plasmids exhibited characteristics common to the 2.6-mdal plasmid, structural lability and sites resistant to cleavage with HpaII. The concatemeric forms of the cryptic plasmid appear to be stable in these strains and do not undergo internal recombination to produce the 2.6-mdal monomer, nor were higher concatemers detected.

References

Jun 1, 1976·Journal of Bacteriology·R S Foster, G C Foster
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Oct 1, 1974·Infection and Immunity·L W MayerS Falkow
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·D B Clewell, D R Helinski
Aug 1, 1981·Infection and Immunity·J R Dillon, M Pauzé
May 1, 1962·The Biochemical Journal·R P NOVICK

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