Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat

European Journal of Pharmacology
Asunción MoránL San Román

Abstract

Using several 5-hydroxytryptamine (5-HT) agonists and antagonists, we attempted to characterize the receptor subtypes involved in the contractile response to 5-HT in the in situ autoperfused rat kidney. An intra-arterial (i.a.) bolus injection of 5-HT (0.00000125 to 0.1 microg/kg) increased renal perfusion pressure in a dose-dependent way but did not affect the systemic blood pressure. The selective 5-HT2 receptor agonist alpha-methyl-5-HT (alpha-methyl-5-hydroxytryptamine) and the non-selective 5-HT2C receptor agonist (1-(3-chlorophenyl)piperazine), m-CPP, caused a local vasoconstrictor effect in the autoperfused rat kidney, whereas BW723C86, a selective 5-HT2B receptor agonist, the 5-HT1 receptor agonist 5-carboxamidotryptamine, 5-CT, and the selective 5-HT3 receptor agonist m-CPBG (1-(m-chlorophenyl)-biguanide) did not modify the renal perfusion pressure. The vasoconstrictor effect elicited by alpha-methyl-5-HT and m-CPP was significantly decreased by ritanserin (a 5-HT2 receptor antagonist), SB 206553 (3,5-Dihydro-5-methyl-N-3pyridinylbenzo[1,2.b:4,5-b']dipyrrole(1H)-carboxamide hydrochloride), a selective 5-HT2B/2C receptor antagonist and enalapril, but was not modified by pretreatment with spiperone (a 5-HT2A receptor ant...Continue Reading

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Citations

Oct 29, 2010·Journal of Neurophysiology·Katherine C MurrayDavid J Bennett
Nov 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yijen A HuangStephen D Roper
Apr 10, 2015·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
May 25, 2015·Vascular Pharmacology·José-Ángel García-PedrazaAsunción Morán
Aug 5, 2017·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
Jul 28, 2020·International Journal of Obesity Supplements·Mauro CataldiObesity Programs of nutrition, Education, Research and Assessment (OPERA) Group
Jan 31, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José Ángel García-PedrazaAsunción Morán
Apr 29, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Gagandeep Kaur, Pawan Krishan
Jul 15, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eldina RizvićMiroslav M Savić

Related Concepts

Anesthesia Procedures
Diastolic Blood Pressure
Dose-Response Relationship, Drug
Kidney
Inotropism
Receptors, Tryptamine
Structure of Renal Artery
Renal Blood Flow
Serotonin Antagonists
Vasoconstrictor Agents

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