Characterization of copper in uterine fluids of patients who use the copper T-380A intrauterine device

Clinica Chimica Acta; International Journal of Clinical Chemistry
Verónica ArancibiaGustavo Lagos

Abstract

The copper intrauterine device (IUD) is a highly effective method of contraception that requires the dissolution of the copper into uterine cavity. However, there is little information about the amount and form of copper in the fluid and whether the presence of this element produces any change in the protein concentration. Twenty-seven women were divided into three groups that had used IUD for about 6 months, 1 year and > or =3 years. The samples were collected during the proliferative phase (Pp), secretory phase (Sp) and menstruation (M). Square-wave anodic stripping voltammetry (SWASV), cyclic voltammetry (CV), high performance liquid chromatography (HPLC) and atomic absorption spectrometry (AAS) were used in this study. Total copper concentrations were between 3.9 and 19.1 micro g/ml. The mean and standard deviations were as follows: 6 months, 11.4+/-4.7 micro g/ml of copper; 1 year, 11.5+/-7.0 micro g/ml of copper; and 3 years, 6.2+/-1.5 micro g/ml of copper. Total proteins were quantified by measuring the area under the chromatographic peaks. The mean areas obtained with uterine fluid samples from women who used IUDs for 6 months, 1 year and 3 years were 290,013, 538,934 and 201,863 arbitrary units (AU), respectively. The ...Continue Reading

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Citations

Dec 1, 2008·Indian Journal of Microbiology·Priyanka LalVikas Pruthi
Apr 30, 2013·Colloids and Surfaces. B, Biointerfaces·Kuan TianXianping Xia
Oct 11, 2011·Acta Biomaterialia·Weiwei ZhangShuizhou Cai
Nov 10, 2011·Contraception·Florencia AlvarezMonica Fernández Lorenzo de Mele
Sep 13, 2015·Contraception·Reshmi RamakrishnanAbi Santhosh Aprem
Oct 28, 2008·Mutation Research·C A GrilloM Fernández Lorenzo de Mele
Aug 21, 2007·Contraception·Juan LiXiwang Wu
Jul 13, 2005·Journal of Biomedical Materials Research. Part a·Chun-Che ShihShing-Jong Lin
Oct 12, 2016·Biological Trace Element Research·Ying LiZeng-Ming Yang
Jan 1, 2004·Toxicology Mechanisms and Methods·Jurij J Hostynek, Howard I Maibach

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