Characterization of cortical spreading depression in adult well-nourished and malnourished rats submitted to the association of pilocarpine-induced epilepsy plus streptozotocin-induced hyperglycemia

Neuroscience Letters
R R G Costa-CruzRubem Carlos Araújo Guedes

Abstract

Spreading depression was characterized in adult rats rendered epileptic by pilocarpine (350 mg/kg, i.p.) and thereafter made hyperglycemic with (i.p.) 60 mg/kg streptozotocin. Groups treated with only one of the above drugs, as well as control groups treated with their vehicles (saline and citrate buffer, respectively) were also studied. The animals treated with pilocarpine or streptozotocin presented, as a common feature, a reduction in the spreading depression propagation rate. However, they differed by the fact that pilocarpine, in some cases, blocked spreading depression propagation, whereas streptozotocin did not block it at all. In early-malnourished animals, streptozotocin-effects, but not pilocarpine-effects on spreading depression were attenuated. The treatment with both drugs did not potentiate their individual reducing effects on spreading depression propagation, irrespective of the animals' early nutritional status. These results extend previous observations on rats treated with both drugs separately, confirming their impairing action on spreading depression propagation. They also indicate that early malnutrition is more effective in changing the streptozotocin effects on spreading depression, as compared to the pil...Continue Reading

References

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Citations

May 23, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Angélica da Silva TenórioRubem Carlos Araújo Guedes
Jun 11, 2008·Alcoholism, Clinical and Experimental Research·Ricardo Abadie-GuedesRanilson de Souza Bezerra
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Ricardo Abadie-GuedesRanilson S Bezerra
Nov 16, 2011·IEEE Transactions on Bio-medical Engineering·H F BassaniR C A Guedes
Jul 16, 2011·Nutritional Neuroscience·Heloisa Mirelle Costa MonteiroRubem Carlos Araújo Guedes
May 16, 2012·Nutritional Neuroscience·R C A GuedesRanilson de Souza Bezerra
Nov 21, 2007·Nutritional Neuroscience·Katia Karina Do Monte-SilvaRubem Carlos Araújo Guedes
Jul 22, 2008·Neuroscience Letters·Rubem Carlos Araújo Guedes, Carlos Augusto Carvalho de Vasconcelos
Jul 23, 2013·Life Sciences·Cássia Borges LimaRubem Carlos Araújo Guedes
Mar 19, 2013·European Journal of Pharmacology·Angela Amancio-Dos-SantosRubem Carlos Araújo Guedes

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