Abstract
The aims of this study were to characterize the curcumin/cyclodextrin polymer inclusion complex using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and UV⁻vis spectroscopy, and to determine the antioxidant activity of this complex by methods of scavenging 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals assays and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals assays. The inhibitory effect of inclusion complex on A375 cells was also investigated by CCK-8 assay, Annexin-V/PI staining assay, and caspase activity assay. The results showed that the complex exhibited different physicochemical characteristics from that of free curcumin. Moreover, the inclusion complex exhibited novel antioxidant activity by scavenging the ABTS and DPPH free radicals and displayed higher antiproliferative activity on A375 cells. Further investigation revealed that inclusion complex could induce A375 cell apoptosis. These findings suggest that inclusion complex could be developed as a novel natural antioxidant with potential applications in cancer chemoprevention.
References
Apr 22, 1996·FEBS Letters·N J MillerC A Rice-Evans
Feb 7, 2001·Journal of Agricultural and Food Chemistry·Y Okada, M Okada
Sep 18, 2004·Immunogenetics·Scott LongV Gregory Chinchar
Feb 9, 2010·Biochemical Pharmacology·Jayaraj RavindranBharat B Aggarwal
Mar 9, 2011·Journal of Agricultural and Food Chemistry·Vanessa Aparecida MarcolinoGraciette Matioli
Feb 11, 2012·Pharmaceutical Research·Prasad R DandawateFazlul H Sarkar
May 1, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Yibo ZhangTianfeng Chen
Jun 13, 2012·Chemical & Pharmaceutical Bulletin·Jianyu SuXiong Ding
Aug 10, 2012·Inorganic Chemistry·Bo YuTianfeng Chen
Apr 27, 2013·Carbohydrate Polymers·Wang ZhangGuowang Diao
Feb 5, 2014·Food Chemistry·Camila Sampaio MangolimGraciette Matioli
Oct 11, 2014·Journal of Pharmaceutical Sciences·Annalisa CutrignelliMassimo Franco
Aug 8, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xing ChenCheng-Mei Liu
Oct 25, 2016·Biomacromolecules·Xia SongJun Li
Jan 1, 2017·Carbohydrate Polymers·Yongqin WeiHao Liang
Dec 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yinghua LiTianfeng Chen
Citations
Dec 24, 2019·Journal of Food Biochemistry·Jianping ChenYinghua Li
Oct 2, 2019·Current Drug Metabolism·Desu N K ReddyFu-Yung Huang
May 5, 2020·Advanced Healthcare Materials·Xingwu ZhouAli Khademhosseini
Jul 14, 2019·AAPS PharmSciTech·Karthikeyan Selvaraj, Bong-Kyu Yoo
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danni ZhengYuxiang Bai
Apr 30, 2020·International Journal of Nanomedicine·Heshu Sulaiman RahmanNoorjahan Banu Alitheen
Aug 19, 2020·Drug Development and Industrial Pharmacy·Mohammed JafarSyed Sarim Imam
Sep 26, 2020·Polymers·Nóra Zsuzsanna NagyÉva Kiss
Mar 27, 2021·Journal of Biomaterials Science. Polymer Edition·Deepika Sharma, Bhabani K Satapathy
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Layan DahabraMouhamad Khoder
Apr 16, 2021·International Journal of Nanomedicine·Islam M AdelNermeen A Elkasabgy
Jun 3, 2021·Polymers·Adrián MatencioFrancesco Trotta
May 28, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Islam M AdelNermeen A Elkasabgy
Nov 24, 2020·ACS Omega·Ee Taek HwangJangyong Kim