Characterization of cyclic peptides containing disulfide bonds

Journal of Pharmaceutical and Biomedical Analysis
Mindy JohnsonKanthi Hettiarachchi

Abstract

Unlike linear peptides, analysis of cyclic peptides containing disulfide bonds is not straightforward and demands indirect methods to achieve a rigorous proof of structure. Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and the results are presented in this paper. The great potential of two dimensional NMR and ESI tandem mass spectrometry was harnessed during the course of peptide characterizations. A new RP-HPLC method for the analysis of trifluoroacetic acid is also presented. It is robust, simple, and efficient compared to the currently available methods.

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Citations

May 17, 2018·Beilstein Journal of Organic Chemistry·Eirinaios I VrettosAndreas G Tzakos
Jun 30, 2019·Journal of the American Society for Mass Spectrometry·David J ForemanScott A McLuckey
Apr 25, 2017·ACS Medicinal Chemistry Letters·Azzurra StefanucciAdriano Mollica

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