Characterization of Cyclodextrin/Volatile Inclusion Complexes: A Review

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Miriana KfourySophie Fourmentin

Abstract

Cyclodextrins (CDs) are a family of cyclic oligosaccharides that constitute one of the most widely used molecular hosts in supramolecular chemistry. Encapsulation in the hydrophobic cavity of CDs positively affects the physical and chemical characteristics of the guests upon the formation of inclusion complexes. Such a property is interestingly employed to retain volatile guests and reduce their volatility. Within this scope, the starting crucial point for a suitable and careful characterization of an inclusion complex is to assess the value of the formation constant (Kf), also called stability or binding constant. This task requires the application of the appropriate analytical method and technique. Thus, the aim of the present paper is to give a general overview of the main analytical tools used for the determination of Kf values for CD/volatile inclusion complexes. This review emphasizes on the advantages, inconvenients and limits of each applied method. A special attention is also dedicated to the improvement of the current methods and to the development of new techniques. Further, the applicability of each technique is illustrated by a summary of data obtained from the literature.

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Citations

Apr 17, 2020·Polymers·Elisa Mele
Dec 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiba Mohamed AmeenBeáta Lemli
Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fabricio Maestá BezerraAndré Luiz Tessaro
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae-Ung LeeHan Bin Oh
Jun 23, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takahiro SakaiIzuru Kawamura
Dec 15, 2020·Journal of the Science of Food and Agriculture·Santiago López-MirandaRafael Pagán
Dec 31, 2020·Nanomaterials·Carolina Belenguer-SapiñaPedro Amorós
Dec 22, 2020·Frontiers in Nutrition·Antonio López-GómezGinés Benito Martínez-Hernández
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui GuoLee D Wilson
Jun 3, 2021·Polymers·Adrián MatencioFrancesco Trotta
Jul 24, 2021·Carbohydrate Polymers·Zuobing XiaoXingran Kou
Sep 8, 2021·Environmental Science and Pollution Research International·Somenath Panda, Sophie Fourmentin

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Methods Mentioned

BETA
nuclear magnetic resonance
fluorescence spectroscopy
NMR
Isothermal Titration Calorimetry
solubility studies

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