Characterization of cytological changes, IgA, IgG and IL-8 levels and pH value in the vagina of prepubertal and sexually mature Ellegaard Göttingen minipigs during an estrous cycle

Developmental and Comparative Immunology
Emma LorenzenGregers Jungersen

Abstract

The pig is increasingly used as an advanced animal model of the genital tract in women and knowledge on the genital immune system is therefore needed. In this study, evaluation of vaginal smears revealed that almost no neutrophils or other leukocytes were present in the vaginal mucosa of prepubertal minipigs (n = 10). In sexually mature minipigs (n = 10), evaluated through an estrous cycle, there was an increase in number of mucosal neutrophils and other leukocytes during estrus. The level of total IgA on the vaginal mucosa increased during diestrus. The level of total IgG showed no significant changes through the cycle. The vaginal IgA level in the prepubertal minipigs was similar to the low estrus level in sexually mature minipigs, and the IgG level in prepubertal was similar to the stable level in the sexually mature minipigs.

References

Jun 1, 1997·American Journal of Obstetrics and Gynecology·J C CaillouetteS Roy
Jun 24, 2000·Microbes and Infection·S Boris, C Barbés
Feb 28, 2003·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lydia A ShrierPeggy A Crowley-Nowick
Aug 7, 2003·Journal of the National Cancer Institute·Denise Nardelli-HaefligerPierre De Grandi
May 19, 2005·International Journal of STD & AIDS·Satyajit DasSriskandab Allan
Oct 7, 2005·Archives of Gynecology and Obstetrics·Miranda Farage, Howard Maibach
Aug 28, 2007·Journal of Pharmaceutical Sciences·Christopher A SquierCatherine C Davis
Feb 6, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Driss El KebirJános G Filep
Sep 11, 2010·Nature Reviews. Immunology·Akiko Iwasaki
Jan 13, 2011·American Journal of Reproductive Immunology : AJRI·Peter F Wright
Apr 19, 2011·Seminars in Musculoskeletal Radiology·Kieran J Murphy
May 19, 2011·Future Microbiology·Rachel R Spurbeck, Cindy Grove Arvidson
Oct 31, 2013·Archives of Gynecology and Obstetrics·Sandra BorgesPaula Teixeira
Mar 4, 2014·Pathogens and Disease·Gail L Sturdevant, Harlan D Caldwell
Mar 29, 2014·Toxicologic Pathology·Eveline de RijkBirgit Peter
May 31, 2014·International Journal of Medical Microbiology : IJMM·Paola MastromarinoRosa Sessa

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