Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

Scientific Reports
Alen LovricJ Borén

Abstract

Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. Myocardial and hepatic triglycerides were measured with magnetic spectroscopy while function of left ventricle, pericardial and epicardial fat, subcutaneous and visceral adipose tissue were measured with magnetic resonance imaging. Measured ectopic fat depots were profiled and predicted using a Random Forest algorithm, and by estimating the Area Under the Receiver Operating Characteristic curves. We have identified distinct metabolic signatures of fat depots in the liver (TAG50:1, glutamate, diSM18:0 and CE20:3), pericardium (N-palmitoyl-sphinganine, HGF, diSM18:0, glutamate, and TNFSF14), epicardium (sphingomyelin, CE20:3, PC38:3 and TNFSF14), and myocardium (CE20:3, LAPTGF-β1, glutamate and glucose)...Continue Reading

References

Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
May 16, 1998·The Journal of Clinical Investigation·J A LevineT O'Brien
Apr 4, 2001·The Journal of Clinical Investigation·H C ChiuJ E Schaffer
Oct 29, 2003·Circulation·Tomasz MazurekYi Shi
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Maria E TrujilloSusan K Fried
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
Aug 11, 2006·Arthritis Research & Therapy·Cem Gabay
Aug 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Mikko KankaanpääPatricia Iozzo
Dec 15, 2006·Nature·Luc F Van GaalChristophe E De Block
Aug 19, 2007·Circulation·Jonathan M McGavockLidia S Szczepaniak
Nov 22, 2008·Journal of the American College of Cardiology·Luuk J RijzewijkHildo J Lamb
Jan 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Christer S EjsingAndrej Shevchenko
Apr 7, 2009·Nestlé Nutrition Workshop Series. Paediatric Programme·Vidya Subramanian, Anthony W Ferrante
May 2, 2009·Disease Models & Mechanisms·Paul L Huang
Jun 18, 2009·The Journal of Clinical Endocrinology and Metabolism·Constantinos ChristodoulidesFredrik Karpe
Sep 30, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J BassolsJ M Fernandez-Real
Oct 13, 2009·The Journal of Clinical Endocrinology and Metabolism·Patricia IozzoPirjo Nuutila
Nov 17, 2009·QJM : Monthly Journal of the Association of Physicians·J K DowmanP N Newsome
May 11, 2010·Gastroenterology·Jody DushayEleftheria Maratos-Flier
Oct 6, 2010·Advances in Experimental Medicine and Biology·Christopher R GaultYusuf A Hannun
Oct 12, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Laura ErnandeGeneviève Derumeaux
Mar 16, 2011·The Journal of Clinical Investigation·Eugene P RheeRobert E Gerszten
Dec 14, 2011·Circulation·Kathryn A Britton, Caroline S Fox
Mar 13, 2012·European Heart Journal·Lokpal S BhatiaChristopher D Byrne
Mar 16, 2012·Journal of the American Geriatrics Society·Ramona RamachandranChee W Chia
Jun 6, 2012·Journal of Biomedicine & Biotechnology·Baogang XieHorst Joachim Schirra
Jul 14, 2012·Journal of Molecular and Cellular Cardiology·Petra C KienesbergerJason R B Dyck
Aug 1, 2012·PloS One·Melissa N BarberClinton R Bruce
Feb 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Marit GranérMarja-Riitta Taskinen
Nov 16, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Kristofer NymanKirsi Lauerma
Jul 16, 2014·World Journal of Gastroenterology : WJG·Hong Liu, Hong-Yun Lu

❮ Previous
Next ❯

Citations

Sep 8, 2020·Expert Review of Gastroenterology & Hepatology·Letícia F RamosKaren C M Moraes
Apr 20, 2019·F1000Research·Carlos A Aguilar-Salinas, Tannia Viveros-Ruiz
Jul 25, 2019·Nutrients·Adil MardinogluJan Borén
Sep 22, 2020·Biochimica Et Biophysica Acta. General Subjects·Ilaria ZanottiLisa Elviri
Aug 14, 2021·Journal of Lipid Research·Olga VvedenskayaAndrej Shevchenko

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
metabolomics profiling

Software Mentioned

R Development Core
jMRUI
R
Impax
Metabolome

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.