PMID: 8449387Feb 1, 1993Paper

Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J LlorensW R Mundy

Abstract

These experiments examined the relationship between behavioral alterations and neurochemical changes in rats exposed repeatedly to disulfoton, an organophosphate cholinesterase inhibitor. Male Long-Evans rats were injected ip for 30 days with 0, 0.5, 1, or 2 mg/kg of disulfoton in corn oil. Clinical signs and motor activity were measured during the course of repeated exposure. Cognitive function, as measured in the Morris water maze, and passive avoidance procedures were assessed near the end of the dosing regimen. Regional brain acetylcholinesterase (AChE) activity was measured during the course of dosing while the total number of muscarinic receptors was measured at the end of the dosing regimen. Tolerance developed rapidly to the clinical signs produced by disulfoton, but not to the disulfoton-induced decrease in motor activity. Disulfoton affected the acquisition of water maze performance, but had no effect on passive avoidance acquisition or retention. Repeated exposure to disulfoton decreased brain AChE activity and the number of [3H]quinuclidinyl benzilate binding sites. These data indicate that, in spite of muscarinic receptor down-regulation that followed repeated exposure to disulfoton, animals become tolerant to only...Continue Reading

Citations

Nov 1, 1994·Neurotoxicology and Teratology·J LlorensD B Peele
Aug 1, 1994·Journal of Pharmacological and Toxicological Methods·R D Jones, N P Greufe
Dec 4, 2002·Neurotoxicology and Teratology·C G CastilloM E Jiménez-Capdeville
Oct 29, 2014·Canadian Journal of Physiology and Pharmacology·Shamsherjit KaurAtish Prakash
Jul 12, 2001·Toxicology and Applied Pharmacology·D A JettG L McLemore
Jul 7, 2007·Human & Experimental Toxicology·Virginia C Moser
Mar 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Fernando CañadasFernando Sánchez-Santed
Jan 30, 2004·The Journal of Toxicological Sciences·Tingting SunIng K Ho
May 20, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·V C MoserS Padilla

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