PMID: 7543591Sep 1, 1995Paper

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias

Journal of Virology
S C CoseF R Carbone

Abstract

The glycoprotein B (gB) from herpes simplex virus type I is a major target of cytotoxic T lymphocytes (CTL) in C57BL/6 mice. The majority of these T cells are directed to a single Kb-restricted determinant, gB498-505. We have analyzed the T-cell receptor (TCR) usage in gB-specific CTL lines derived shortly after virus infection. The CTL populations preferentially used two V beta regions, a dominant V beta 10 element and a subdominant V beta 8 element. Detailed sequence analysis revealed considerable TCR beta-chain heterogeneity despite a striking level of predicted amino acid conservation at the V beta-D beta junction. This junction forms part of the third hypervariable loop of the TCR thought to directly contact the major histocompatibility complex-bound antigenic peptide. The results reveal considerable diversity within the primary T cells responding to a single viral determinant while still maintaining a high degree of TCR V beta bias and sequence conservation at the V-D-J junction.

References

Aug 1, 1992·The Journal of Experimental Medicine·J L CasanovaJ L Maryanski
Jan 1, 1992·Immunogenetics·K TomonariH Hengartner
Jan 1, 1990·Annual Review of Immunology·L A Matis
Jan 1, 1989·Immunology Today·J M ClaverieL Bougueleret
Feb 1, 1987·The Journal of Experimental Medicine·S B SorgerL A Matis
Aug 4, 1988·Nature·M M Davis, P J Bjorkman
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A BehlkeD Y Loh
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H S ChouD Y Loh
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J NovotnýH N Eisen

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Citations

Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R DyallJ Nikolic-Zugić
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·I MessaoudiJ Nikolich-Zugich
Nov 5, 2002·Annual Review of Immunology·Phillip Wong, Eric G Pamer
Aug 4, 2004·The Journal of Experimental Medicine·Dirk Meyer-OlsonSpyros A Kalams
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilhem MessaoudiJanko Nikolich-Zugich
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lichen JingDavid M Koelle
Feb 9, 2011·Immunology and Cell Biology·John J MilesDavid A Price
Jul 7, 1998·The Journal of Experimental Medicine·D H BuschE G Pamer
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·James V Brawley, Patrick Concannon
Jul 11, 2006·Folia Microbiologica·J Rajcáni, V Durmanová
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna LangJanko Nikolich-Zugich
Nov 18, 2006·Nature Reviews. Immunology·Stephen J TurnerJamie Rossjohn
Feb 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian D RuddJanko Nikolich-Zugich
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Silvia AriottiTon N Schumacher
Mar 26, 2004·Nature Reviews. Immunology·Janko Nikolich-ZugichIlhem Messaoudi
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M PosavadL Corey
May 11, 2005·Immunological Reviews·Eric T ClambeyPhilippa Marrack
Jan 25, 2006·International Immunology·Mihyung KimKi-Young Lee
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Todd R Wuest, Daniel J J Carr
Apr 10, 2002·Immunology and Cell Biology·Scott N MuellerClaerwen M Jones
Jan 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian D RuddJanko Nikolich-Zugich
Jul 25, 2006·Infection and Immunity·Dennis M LindellGary B Huffnagle
Feb 17, 1999·The Journal of Experimental Medicine·D H Busch, E G Pamer
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D M KoelleL Corey
Nov 17, 2004·The Journal of Experimental Medicine·Ilhem MessaoudiJanko Nikolich-Zugich
Mar 28, 2008·Nature Reviews. Microbiology·Anne H RowleyStanford T Shulman
Nov 10, 2005·Immunology and Cell Biology·Ann L CornishDale I Godfrey
Aug 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brian D RuddJanko Nikolich-Žugich
Nov 28, 2000·European Journal of Immunology·N L La GrutaP A Gleeson

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