PMID: 375073Feb 1, 1979Paper

Characterization of DNA adenine methylation mutants of Escherichia coli K12

Mutation Research
A BaleM G Marinus

Abstract

The phenotypic traits of 7 independently isolated dam mutants of Escherichia coli have been examined. The mutant strains differ from the wildtype in the following respects: (1) decreased DNA adenine methylase activity in vivo and in vitro; (2) a 14--85-fold increase in spontaneous mutability; (3) decreased survival after ultraviolet irradiation; (4) a 10--21-fold increase in spontaneous induction of lambda phage from lysogens; (5) a 3--17-fold increase in the level of recombination; and (6) inviability of double mutants containing dam- and recB- or recC-. Unmethylated fd phage chromosomes are able to replicate normally in dam- mutants. A mutant strain in which the dcm gene is deleted is viable, showing that the dcm gene product is dispensible for growth.

References

Dec 22, 1976·Molecular & General Genetics : MGG·M G Marinus, E B Konrad
Nov 11, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Wagner, M Meselson
Jun 1, 1973·Journal of Bacteriology·M G Marinus, N R Morris
Dec 14, 1973·Molecular & General Genetics : MGG·M G Marinus
May 15, 1974·Journal of Molecular Biology·M G Marinus, N R Morris
Feb 14, 1968·Journal of Molecular Biology·C Lark
Feb 14, 1968·Journal of Molecular Biology·D Billen
Mar 24, 1971·Nature: New Biology·N GuerolaE Cerdá-Olmedo
Oct 1, 1957·Journal of Bacteriology·S E LURIA, J W BURROUS
Jul 1, 1950·Journal of Bacteriology·B D DAVIS, E S MINGIOLI
Apr 12, 2005·Science·Uwe H F Bunz

❮ Previous
Next ❯

Citations

Jan 1, 1983·Molecular & General Genetics : MGG·M G MarinusJ A Arraj
May 1, 1989·Molecular & General Genetics : MGG·P JonczykD W Smith
Oct 1, 1988·Molecular & General Genetics : MGG·E P EfimovaA A Belogurov
Jan 1, 1992·Folia Microbiologica·J Hubácek
Jul 1, 1985·Mutation Research·N J Sargentini, K C Smith
Nov 1, 1985·Mutation Research·W Tröbner, R Piechocki
Jan 1, 1986·Mutation Research·R J FramM G Marinus
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B W Glickman, M Radman
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R T FraleyS C Woo
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B CamiP Kourilsky
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Lieb, S Rehmat
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Josep Casadesús, David Low
Aug 26, 2003·Nature Structural Biology·Zhe YangXiaodong Cheng
Oct 3, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chi-Tai FangShih-Feng Tsai
Mar 22, 2016·Nature Genetics·Nadia R CohenJames J Collins
Oct 25, 2016·Virus Evolution·Marianoel Pereira-Gómez, Rafael Sanjuán
Apr 29, 1982·Nature·P Karran, M G Marinus
May 1, 1995·Molecular Microbiology·A Kuzminov
Jan 1, 1980·Environmental Mutagenesis·P E Hartman
Oct 17, 2020·Critical Reviews in Biochemistry and Molecular Biology·Taylor M NyeLyle A Simmons
Feb 1, 1984·Journal of Virology·B Auer, M Schweiger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.