PMID: 3083254Mar 1, 1986

Characterization of dolichol monophosphate- and dolichol diphosphate-linked saccharides in trypanosomatid flagellates

Molecular and Biochemical Parasitology
J O PreviatoA J Parodi


Dolichol-P- and dolichol-P-P-linked saccharides were isolated from several trypanosomatid flagellates incubated with [U-14C]glucose. Formation of Glc-P-dolichol and Man-P-dolichol was observed in Herpetomonas muscarum and Leishmania adleri, whereas only the latter derivative was synthesized in Trypanosoma dionisii and Leptomonas samueli. The main and largest dolichol-P-P-linked oligosaccharide formed in Trypanosoma conorhini, T. dionisii, L. samueli, Herpetomonas samuelpessoai and H. muscarum appeared to be Man9GlcNAc2, whereas in Blastocrithidia culicis it was Man6GlcNAc2. In L. adleri there were two main oligosaccharides linked to dolichol-P-P, Man6GlcNAc2 and Man5GlcNAc2. The The structures of the oligosaccharides were identical with those of the intermediates in the formation of Glc3Man9GlcNAc2-P-P-dolichol in higher eucaryotes. It was concluded that similarly to Trypanosoma cruzi, Crithidia fasciculata and Leishmania mexicana, no glucosylated derivatives of dolichol-P-P were formed in the additional seven trypanosomatids studied here. The results obtained suggest that the defective step could be in some cases the formation of Glc-P-dolichol and in others, the transfer of glucose residues from the latter compound to dolicho...Continue Reading


Mar 1, 1986·Molecular and Biochemical Parasitology·D H MendelzonA J Parodi
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T C Huffaker, P W Robbins
Jan 13, 1984·Biochemical and Biophysical Research Communications·A J ParodiJ C Engel
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A J ParodiJ J Cazzulo
Jan 1, 1981·Annual Review of Biochemistry·S C Hubbard, R J Ivatt
Aug 1, 1981·Archives of Biochemistry and Biophysics·A J Parodi
Apr 1, 1980·European Journal of Biochemistry·R J StaneloniL F Leloir


Mar 1, 1986·Molecular and Biochemical Parasitology·D H MendelzonA J Parodi
Jan 2, 1987·Molecular and Biochemical Parasitology·J K Lovelace, M Gottlieb
Jan 1, 1988·The Journal of Cell Biology·M DuszenkoG A Cross
Dec 25, 2007·Experimental Parasitology·Denise Costa ArrudaSilvia Reni B Uliana

Related Concepts

Acetic Acids
Dolichol Monophosphates
Terpene Phosphates
Puromycin Hydrochloride

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

© 2021 Meta ULC. All rights reserved