PMID: 3083254Mar 1, 1986

Characterization of dolichol monophosphate- and dolichol diphosphate-linked saccharides in trypanosomatid flagellates

Molecular and Biochemical Parasitology
J O PreviatoA J Parodi

Abstract

Dolichol-P- and dolichol-P-P-linked saccharides were isolated from several trypanosomatid flagellates incubated with [U-14C]glucose. Formation of Glc-P-dolichol and Man-P-dolichol was observed in Herpetomonas muscarum and Leishmania adleri, whereas only the latter derivative was synthesized in Trypanosoma dionisii and Leptomonas samueli. The main and largest dolichol-P-P-linked oligosaccharide formed in Trypanosoma conorhini, T. dionisii, L. samueli, Herpetomonas samuelpessoai and H. muscarum appeared to be Man9GlcNAc2, whereas in Blastocrithidia culicis it was Man6GlcNAc2. In L. adleri there were two main oligosaccharides linked to dolichol-P-P, Man6GlcNAc2 and Man5GlcNAc2. The The structures of the oligosaccharides were identical with those of the intermediates in the formation of Glc3Man9GlcNAc2-P-P-dolichol in higher eucaryotes. It was concluded that similarly to Trypanosoma cruzi, Crithidia fasciculata and Leishmania mexicana, no glucosylated derivatives of dolichol-P-P were formed in the additional seven trypanosomatids studied here. The results obtained suggest that the defective step could be in some cases the formation of Glc-P-dolichol and in others, the transfer of glucose residues from the latter compound to dolicho...Continue Reading

References

Mar 1, 1986·Molecular and Biochemical Parasitology·D H MendelzonA J Parodi
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T C Huffaker, P W Robbins
Jan 13, 1984·Biochemical and Biophysical Research Communications·A J ParodiJ C Engel
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A J ParodiJ J Cazzulo
Jan 1, 1981·Annual Review of Biochemistry·S C Hubbard, R J Ivatt
Aug 1, 1981·Archives of Biochemistry and Biophysics·A J Parodi
Apr 1, 1980·European Journal of Biochemistry·R J StaneloniL F Leloir

Citations

Mar 1, 1986·Molecular and Biochemical Parasitology·D H MendelzonA J Parodi
Jan 2, 1987·Molecular and Biochemical Parasitology·J K Lovelace, M Gottlieb
Jan 1, 1988·The Journal of Cell Biology·M DuszenkoG A Cross
Dec 25, 2007·Experimental Parasitology·Denise Costa ArrudaSilvia Reni B Uliana

Related Concepts

Acetic Acids
Beta-N-Acetylglucosaminidase
Metazoa
Actidione
Dolichol Monophosphates
Glycolipids
Mannosidase
Terpene Phosphates
Puromycin Hydrochloride
Leptomonas

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