Characterization of duck H5N1 influenza viruses with differing pathogenicity in mallard (Anas platyrhynchos) ducks

Avian Pathology : Journal of the W.V.P.A
Yinghua TangXiufan Liu

Abstract

A number of H5N1 influenza outbreaks have occurred in aquatic birds in Asia. As aquatic birds are the natural reservoir of influenza A viruses and do not usually show clinical disease upon infection, the repeated H5N1 outbreaks have highlighted the importance of continuous surveillance on H5N1 viruses in aquatic birds. In the present study we characterized the biological properties of four H5N1 avian influenza viruses, which had been isolated from ducks, in different animal models. In specific pathogen free (SPF) chickens, all four isolates were highly pathogenic. In SPF mice, the S and Y isolates were moderately pathogenic. However, in mallard ducks, two isolates had low pathogenicity, while the other two were highly pathogenic and caused lethal infection. A representative isolate with high pathogenicity in ducks caused systemic infection and replicated effectively in all 10 organs tested in challenged ducks, whereas a representative isolate with low pathogenicity in ducks was only detected in some organs in a few challenged ducks. Comparison of complete genomic sequences from the four isolates showed that the same amino acid residues that have been reported to be associated with virulence and host adaption/restriction of infl...Continue Reading

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Citations

Oct 1, 2010·Archives of Virology·J L WasilenkoM J Pantin-Jackwood
Aug 7, 2013·Virus Research·Mary J Pantin-Jackwood, David L Suarez
Jan 8, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Hendra WibawaJoanne Meers
May 12, 2012·Molecular Ecology·Tommy Tsan-Yuk LamFrederick Chi-Ching Leung
Jan 28, 2015·Emerging Infectious Diseases·Hyun-Mi KangYoun-Jeong Lee
Aug 26, 2016·Journal of Virology·Mary J Pantin-JackwoodDavid E Swayne
Dec 20, 2018·International Journal of Veterinary Science and Medicine·Shimaa M G MansourAmal A M Eid
May 1, 2020·Transboundary and Emerging Diseases·Sujuan ChenXiufan Liu

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Datasets Mentioned

BETA
EU195389
EU195420

Methods Mentioned

BETA
PCR
electrophoresis
sedation
glycosylation

Software Mentioned

PAUP
PAUP *
LASERGENE

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