Characterization of effector components from the humoral and cellular immune response stimulated by melanoma cells exhibiting modified IGF-1 expression

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Chaobin ZhuHuynh-Thien Duc

Abstract

Modified melanoma B16 cells inhibited in their IGF-1 expression (B16MOD), on the contrary to the IGF-1 fully expressed parental wild-type (B16WT) counterpart, were shown to stimulate humoral as well as cellular immune responses. Among humoral components, the neutralizing and complement-fixing antibodies of IgM and essentially IgG2 (a+b) isotypes exhibited in vitro and in vivo effects upon tumour growth, while the IgG1 antibody isotype promoted enhanced tumour proliferation. As for the cellular immunity, it was found that the T CD8(+) lymphocyte subpopulation remained the main potent and long lasting immune active effector regulating tumour growth.

References

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Oct 31, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S TrabadoH-T Duc
Sep 4, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Séverine TrabadoHuynh-Thien Duc

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