PMID: 9437582Jan 23, 1998Paper

Characterization of endocrine events during the periestrous period in sheep after estrous synchronization with controlled internal drug release (CIDR) device

Domestic Animal Endocrinology
J Van CleeffV Padmanabhan

Abstract

The Controlled Internal Drug Releasing (CIDR) device is an intravaginal pessary containing progesterone (P4) designed for synchronizing estrus in ruminants. To date, there has been little information available on the timing, duration, and quality of the follicular phase after CIDR removal and how those characteristics compare with natural periovulatory endocrine events. The present communication relates the results of methods we used to characterize the endocrine events that followed CIDR synchronization. Breeding-season ewes were given an injection (10 mg) of Lutalyse (PGF2 alpha), and then studied during three consecutive estrous cycles, beginning in the luteal phase after the estrus induced by PGF2 alpha. Cycle 1 estrus was synchronized with 1 CIDR (Type G) inserted for 8 d beginning 10 d after PGF2 alpha. Cycles 2 and 3 were synchronized with two CIDRs for 8 d beginning 10 d after previous CIDR removal. Cycle 1 estrous behavior and serum gonadotropins showed a follicular phase (the interval from CIDR withdrawal to gonadotropin surge [surge] peak) of 38.2 +/- 1.5 hr. Two CIDRs lengthened the interval to 46.2 +/- 1.5 hr (P < 0.0001). At CIDR removal, circulating P4 concentrations were higher in ewes treated with two CIDRs (5....Continue Reading

References

May 1, 1969·Endocrinology·G D NiswenderA V Nalbandov
Aug 1, 1967·Journal of Reproduction and Fertility·S D ParsonsA A Rayner
Jan 1, 1996·Domestic Animal Endocrinology·S K JohnsonP E Lewis

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Citations

Feb 19, 2010·Biology of Reproduction·Elizabeth R WagenmakerFred J Karsch
Jul 27, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Achraf AdibMaria-Teresa Pellicer-Rubio
Mar 5, 2013·Toxicology and Applied Pharmacology·Bachir Abi SalloumVasantha Padmanabhan
Mar 23, 2011·Journal of Neuroendocrinology·K M SheppardM N Lehman
Nov 11, 2010·Journal of Veterinary Pharmacology and Therapeutics·J D RoweD Hallford
Aug 4, 2009·Journal of Veterinary Pharmacology and Therapeutics·J D RoweD C Wagner
Jun 21, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Gabriela Azenha Milani SorianoCaliê Castilho
Nov 25, 2020·Animals : an Open Access Journal From MDPI·Anna J KorzekwaRoland Kozdrowski

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