Characterization of endothelium-dependent relaxation and modulation by treatment with pioglitazone in the hypercholesterolemic rabbit renal artery

European Journal of Pharmacology
Hiroko MoroeHiroshi Kogo

Abstract

The present study was undertaken to investigate vascular function in hypercholesterolemic rabbits and also to characterize the effects of pioglitazone on it. Rabbits were fed normal, 0.5% cholesterol chow, or 0.5% cholesterol chow plus 300 ppm pioglitazone for 5 or 10 weeks. The tension of isolated renal artery rings was measured isometrically, and morphometric analysis was performed. The cholesterol chow diet administered for 5 weeks did not affect acetylcholine-induced relaxation in the renal artery but that for 10 weeks decreased it. The N(G)-nitro-L-arginine (L-NOARG)- and indomethacin-resistant endothelium-dependent relaxation induced by acetylcholine in the renal artery was enhanced in rabbits receiving the cholesterol chow for 5 or 10 weeks, as compared to rabbits receiving the control diet, and the percentage of plaque area formation was increased in the renal artery by the cholesterol chow for 10 weeks. Pioglitazone normalized them without lowering serum lipid levels. The resistant parts of acetylcholine-induced relaxation was significantly inhibited when the renal artery was treated with charybdotoxin, an inhibitor of large and intermediate conductance Ca(2+)-activated K(+) channels, or N,N-diethylaminoethyl-2,2-diphe...Continue Reading

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Citations

Apr 27, 2007·Nihon rinsho. Japanese journal of clinical medicine·Toshikazu Yamanouchi
Jul 29, 2008·Atherosclerosis·Leanid LukshaKarolina Kublickiene
Sep 7, 2007·European Journal of Pharmacology·Silvia LlorensEduardo Nava
Aug 19, 2008·Fundamental & Clinical Pharmacology·Jeremy BellienRobinson Joannides
Jan 22, 2005·European Journal of Pharmacology·Takeshi IwataYoko Notoya
Oct 13, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hiroko Moroe, Hideo Honda
Oct 18, 2005·European Journal of Pharmacology·Akira IshihataYumi Katano
Jul 26, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·H HondaM Kondo
Feb 26, 2008·Experimental Biology and Medicine·Makoto FujimotoYutaka Shimada
Jan 7, 2006·Treatments in Endocrinology·Kathryn Reynolds, Ronald B Goldberg

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