Characterization of epithelial oral dysplasia in non-smokers: First steps towards precision medicine

Oral Oncology
L D RockD M Laronde

Abstract

Tobacco usage is the strongest risk factor in the development of oral squamous cell carcinoma (OSCC), which mandates careful screening for oral cancers in smokers. However, there are indications that oral potentially malignant lesions, such as oral epithelial dysplasia (OED), in non-smokers (NS) have a higher cancer risk than those in smokers. Without tobacco as an etiology, the development of these lesions in NS may suggest genetic susceptibility. The increasing incidence of OSCC in NS calls for a better understanding of the natural history of OED in NS as compared to that of smokers. Patients from a population-based longitudinal study with more than 10 years of follow up were analyzed. Of the 455 patients with primary OED (233 mild and 212 moderate dysplasia), 139 were NS and 306 were smokers. Demographic and habit information, clinical information (lesion site, size and appearance; toluidine blue and fluorescent visualization), microsatellite analysis for loss of heterozygosity (LOH) and outcome (progression) were compared between the two groups. The majority of patients with OED were smokers. Of these, more were males, non-Caucasians and heavy drinkers. A significantly higher number of OED in NS were in the tongue, whereas ...Continue Reading

Citations

Apr 22, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jorge de la OlivaLlucia Alos
Nov 21, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Letícia Martins GuimarãesCarolina Cavalieri Gomes
Aug 28, 2019·Cancer Prevention Research·Katelin D CherryRebecca Richards-Kortum
Mar 9, 2021·Expert Review of Molecular Diagnostics·Kenneth P H PritzkerDavid Mock
Aug 8, 2021·Cancers·Caroline McCarthyRichard J Shaw
Nov 20, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hans Prakash SathasivamMax Robinson

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