PMID: 7540744Mar 1, 1995Paper

Characterization of epitopes on excretory-secretory antigens of Taenia saginata metacestodes recognized by monoclonal antibodies with immunodiagnostic potential

Parasite Immunology
E DraelantsStanny Geerts

Abstract

Four monoclonal antibodies (MoAbs) produced against the excretory-secretory (ES) antigens of Taenia saginata metacestodes are currently used for the detection of circulating antigen in the sera of cattle with bovine cysticercosis. The epitopes recognised by these MoAb were characterized by periodate oxidation, alkaline borohydride and heat treatment, trichloracetic acid precipitation, enzymatic proteolysis and deglycosylation of the ES-products. These results together with those of the homologous sandwich, inhibition and competition ELISAs showed that three repetitive epitopes are recognized, which are present on the tegument and on the ES-products of T. saginata metacestodes. They are different from phosphorylcholine and seem to be either of carbohydrate or partly carbohydrate/partly protein nature.

Citations

Apr 1, 1996·International Journal for Parasitology·S W TanM Singh
Aug 30, 2001·Journal of Clinical Microbiology·A X PardiniJ A Livramento
Jul 1, 2011·Tropical Parasitology·Subhash Chandra Parija, Ar Gireesh
Jan 9, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Venkata Raghava MohanRajshekhar Vedantam
Dec 26, 2012·Pathogens and Global Health·Silvia RodriguezPierre Dorny
Jan 20, 2010·Trends in Parasitology·Nynke Deckers, Pierre Dorny
Jan 18, 2019·The American Journal of Tropical Medicine and Hygiene·Javier A Bustos For The Cysticercosis Working Group In Peru
Jul 5, 2012·Clinical Pharmacology and Therapeutics·M A BarryL Woc-Colburn

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