Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay

Environmental Toxicology and Pharmacology
Radosław CzernychLidia Wolska

Abstract

The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of consumer products. Investigation of estrogenic and androgenic activities of phthalates (DEP, DBP, BBP, DEHP and DINP) showed no significant effect of tested substances either on hERα or hAR receptors. Phthalates exhibited strong anti-estrogenic (IC50 for BBP=8.66μM, IC50 for DEHP=3.61μM and IC50 for DINP=0.065μM) and anti-androgenic (IC50 for BBP=5.30μM, IC50 for DEHP=2.87μM and IC50 for DINP=0.068μM) activities.

Citations

May 19, 2018·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Marek RoszkoBeata Chabłowska
Apr 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Da-Hye KimYoung Jun Kim
Aug 14, 2020·International Journal of Environmental Health Research·Aylin BalcıBelma Kocer-Gumusel
Jun 2, 2020·International Journal of Environmental Health Research·Manel ChebbiVéronique Le Tilly
Oct 31, 2020·Biology of Reproduction·Shuhong YangRomana A Nowak
Feb 19, 2021·American Journal of Public Health·Stephanie M EngelRobin M Whyatt
Mar 18, 2021·Ecotoxicology·Ewa Liwarska-BizukojcKevin M Van Geem

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