PMID: 9524140May 2, 1998Paper

Characterization of ether-à-go-go channels present in photoreceptors reveals similarity to IKx, a K+ current in rod inner segments

The Journal of General Physiology
S FringsA Baumann

Abstract

In this study, we describe two splice variants of an ether-à-go-go (EAG) K+ channel cloned from bovine retina: bEAG1 and bEAG2. The bEAG2 polypeptide contains an additional insertion of 27 amino acids in the extracellular linker between transmembrane segments S3 and S4. The heterologously expressed splice variants differ in their activation kinetics and are differently modulated by extracellular Mg2+. Cooperativity of modulation by Mg2+ suggests that each subunit of the putative tetrameric channel binds a Mg2+ ion. The channels are neither permeable to Ca2+ ions nor modulated by cyclic nucleotides. In situ hybridization localizes channel transcripts to photoreceptors and retinal ganglion cells. Comparison of EAG currents with IKx, a noninactivating K+ current in the inner segment of rod photoreceptors, reveals an intriguing similarity, suggesting that EAG polypeptides are involved in the formation of Kx channels.

References

Dec 1, 1979·The Journal of General Physiology·B OakleyK T Brown
Nov 1, 1979·The Journal of Physiology·C R BaderE A Schwartz
May 1, 1992·The Journal of Physiology·E Neher, G J Augustine
Jan 1, 1988·The Journal of Physiology·K Nakatani, K W Yau
Jan 1, 1989·Annual Review of Neuroscience·K W Yau, D A Baylor
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G H Gold
Nov 17, 1972·Biochimica Et Biophysica Acta·J A Ward, S E Ostroy
Dec 1, 1984·The Journal of Physiology·D A BaylorJ L Schnapf
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G H Gold, J I Korenbrot
Aug 1, 1995·Current Opinion in Neurobiology·U B Kaupp
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·E EismannU B Kaupp
Jan 1, 1994·Annual Review of Biophysics and Biomolecular Structure·F ZufallG M Shepherd
Jun 1, 1994·Current Opinion in Neurobiology·W A SatherR W Tsien
Jun 1, 1995·Current Opinion in Neurobiology·A L Zimmerman
Apr 11, 1994·Neuroscience Letters·D E Kurenny, S Barnes
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J W Warmke, B Ganetzky
Jan 1, 1994·The Journal of General Physiology·L P Wollmuth
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J NakaiK G Beam
Mar 1, 1993·Biochimica Et Biophysica Acta·E N Pugh, T D Lamb
Apr 1, 1993·Trends in Biochemical Sciences·R J Williams
Jan 1, 1993·Annual Review of Physiology·S R Adams, R Y Tsien
Jun 1, 1996·Pflügers Archiv : European journal of physiology·H TerlauS H Heinemann
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C E StansfeldO Pongs
Aug 1, 1996·Current Opinion in Neurobiology·R S Molday
Jan 1, 1996·Annual Review of Physiology·J T FinnK W Yau

❮ Previous
Next ❯

Citations

Feb 24, 2009·European Biophysics Journal : EBJ·Andrea Moriondo, Giorgio Rispoli
Oct 24, 2002·Neurobiology of Aging·Lucio AnnunziatoMaurizio Taglialatela
Nov 18, 2000·British Journal of Pharmacology·M TaglialatelaL Annunziato
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tinatin I BrelidzeWilliam N Zagotta
Mar 29, 2006·The Journal of General Physiology·Sergei S NikonovEdward N Pugh
Jul 6, 2000·The EMBO Journal·R SchönherrS H Heinemann
Jul 22, 1999·Annals of the New York Academy of Sciences·B GanetzkyS A Titus
Jul 29, 2011·American Journal of Physiology. Cell Physiology·Xiaoming ZhangBret A Hughes
Dec 31, 2010·World Journal of Surgical Oncology·Viren AsherRaheela Khan
Oct 25, 2011·PloS One·Tobias KohlWalter Stühmer
Aug 23, 2012·PloS One·Po-Hao HsuChung-Jiuan Jeng
Jul 11, 2012·Sensors·Jesús Adrián Rodríguez-RasgadoJavier Camacho
Jul 4, 2002·The Journal of Physiology·Gian Carlo DemontisDario DiFrancesco
Jan 9, 2016·Pflügers Archiv : European journal of physiology·Halima Ouadid-AhidouchLuis A Pardo
Dec 8, 2007·Neuroscience Letters·Guey-Mei Jow, Chung-Jiuan Jeng
Aug 16, 2005·Biophysical Journal·Günter WrobelAndreas Offenhäusser
Jan 18, 2017·Scientific Reports·Po-Hao HsuChung-Jiuan Jeng
Apr 12, 2002·FEBS Letters·Roland SchönherrStefan H Heinemann
Aug 31, 2007·The European Physical Journal. E, Soft Matter·M PabstA Offenhäusser
Jul 15, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·V Cázares-Ordoñez, L A Pardo
Feb 20, 1999·The Journal of Biological Chemistry·R SchönherrS H Heinemann
Jan 25, 2020·Genes·María de Guadalupe Chávez-LópezJavier Camacho
Sep 15, 2020·Experimental Neurobiology·Jungryul AhnYong Sook Goo
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Michael Madeja
Jun 5, 2013·Molecular Medicine Reports·Yi-Sheng ZhongYi-Hua Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.