PMID: 8590303Nov 1, 1995Paper

Characterization of extrathymic T cells induced by recombinant murine interferon-beta in the peritoneal cavity of nude mice

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
M MoriyamaM Iigo

Abstract

The effects of recombinant murine interferon-beta (rMuIFN-beta) on extrathymic lymphocyte formation in the peritoneal cavity of BALB/c athymic nude mice and tumor-bearing nude mice were examined for comparison with BALB/c normal euthymic mice. The 7 days of administration of 1 x 10(5) IU rMuIFN-beta caused the number of these cells to increase remarkably in the peritoneal cavity as a unique subset of asialoGM1+CD4+CD8-TcR alpha beta+ T cells. The asialoGM1+CD4+ T cells produced IL-2 and IFN-gamma in primary culture without stimulant but did not proliferate. Thus, extrathymic T cells can be induced easily in the peritoneal cavity in addition to the thymus for host defense systems.

References

Jan 1, 1992·Annual Review of Immunology·J J CohenK S Sellins
Oct 1, 1986·Journal of Interferon Research·H KawasakiA Tanaka
Nov 1, 1986·European Journal of Immunology·S HabuK Okumura
Mar 1, 1988·European Journal of Immunology·A Lawetzky, T Hünig
Oct 1, 1986·Journal of Interferon Research·S MatsudaG Kawano
Jan 1, 1993·European Journal of Immunology·H AraseK Onoé

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