Characterization of factors determining Rickettsia tsutsugamushi pathogenicity for mice.

Infection and Immunity
M G Groves, D J Kelly

Abstract

Pathogenicity of Rickettsia tsutsugamushi for laboratory mice is known to be influenced by at least three factors: (i) route of inoculation, (ii) antigenic strain, and (iii) natural resistance of the host. By using Karp, Gilliam, and Kato strains of R. tsutsugamushi, we examined the effect of these three pathogenicity factors on the kinetics of infection and the development of immunity in BALB/cDub and C3H/HeDub mice. The appearance of rickettsemia in the pathogenic infections generally preceded infections of reduced pathogenicity by 1 to 2 days in both magnitude and time of onset. Mice infected by the subcutaneous route with normally pathogenic rickettsiae, i.e., Gilliam-infected C3H/HeDub mice and Karp-infected BALB/cDub mice, consistently maintained a detectable rickettsemia over a 1-year period. Rickettsiae were recovered from the spleens of 95% (19 of 20) of these mice 52 weeks postinfection. In contrast, mice with infections of reduced pathogenicity, i.e., BALB/cDub mice infected by intraperitoneal and subcutaneous inoculation with Gilliam, did not have detectable rickettsemia from week 20 through week 52 postinfection except for a single mouse on week 44 postinfection. Rickettsiae were detected in the spleens of only 40%...Continue Reading

References

Jan 1, 1975·The American Journal of Tropical Medicine and Hygiene·A Shirai, C L Wisseman
Jun 1, 1979·Japanese Journal of Medical Science & Biology·A ShiraiD L Huxsoll
Jan 1, 1977·Infection and Immunity·G H Eisenberg, J V Osterman
Nov 1, 1977·Infection and Immunity·A ShiraiJ V Osterman
Feb 1, 1978·Infection and Immunity·M G Groves, J V Osterman
Mar 1, 1976·Infection and Immunity·P J CatanzaroJ V Osterman
Jun 1, 1986·Infection and Immunity·D J Kelly, J C Rees
Mar 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·F M BOZEMAN, B L ELISBERG
Sep 1, 1950·Annals of the New York Academy of Sciences·J E SMADELH L LEY
Feb 1, 1947·Annals of Internal Medicine·E M IRONS, H E ARMSTRONG
Jun 1, 1946·Proceedings of the Society for Experimental Biology and Medicine·E J BELLL WHITMAN
Mar 1, 1946·The American Journal of Tropical Medicine and Hygiene·E N IRONS
Mar 1, 1946·Proceedings of the Society for Experimental Biology and Medicine·H PLOTZR L REAGAN

❮ Previous
Next ❯

Citations

Jan 1, 1990·Annals of the New York Academy of Sciences·D J KellyM Carl
Jan 30, 2014·Infection & chemotherapy·Min Su KimJae-Seung Kang
Sep 9, 2016·PLoS Neglected Tropical Diseases·Matthias HauptmannChristian A Keller
Oct 2, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tri WangrangsimakulNicholas P J Day
Aug 15, 2014·PLoS Neglected Tropical Diseases·Christian A KellerBernhard Fleischer
Jun 14, 2002·Journal of Medical Entomology·Kriangkrai LerdthusneeRussell E Coleman
Dec 15, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tri WangrangsimakulNicholas P J Day
Aug 5, 2017·Medical Microbiology and Immunology·Anke Osterloh
Oct 3, 2018·Tropical Medicine and Infectious Disease·Alison Luce-FedrowAllen L Richards
Jan 16, 2019·Infection and Immunity·Chanakan SuwanbongkotKevin R Macaluso
May 6, 2019·Tropical Medicine and Infectious Disease·Daryl J KellyAllen L Richards
Feb 28, 2001·Microbes and Infection·S Y SeongI S Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.