Abstract
To assess whether hepatic transit times (HTTs), as measured with contrast material-enhanced ultrasonography (US), can help predict the nature of focal liver lesions. The study was approved by the local institutional ethics committee, with written informed patient consent. A total of 402 patients were enrolled in the study. HTT, the time between the appearance of the microbubble contrast agent in the hepatic artery and its appearance in the hepatic vein, was measured in the contrast pulse sequencing mode after injection of a sulphur hexafluoride microbubble US contrast agent. Logistic regression was used to identify factors indicative of the malignant or nonmalignant status of focal liver lesions. Receiver operating characteristic (ROC) analysis was performed to determine the predictive value of the HTT. Observed HTTs for malignant focal liver lesions (mean, 6.2 seconds; range, 2-10 seconds) were significantly lower than those for nonmalignant lesions (mean, 9.5 seconds; range, 4-25 seconds; P < .001). ROC analysis revealed cutoff values of 7 seconds for HTT and 0.879 for area under the ROC curve. For HTTs of 7 seconds or shorter, hepatic malignancies were detected with a sensitivity of 79%, a specificity of 80%, a positive pred...Continue Reading
References
Nov 17, 1998·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·M D SeemannM F Reiser
Dec 9, 1998·Radiology·M J BlomleyR Schlief
May 20, 1999·Lancet·T AlbrechtN Patel
Mar 11, 2000·Lancet·C J HarveyD O Cosgrove
Apr 24, 2001·Ultrasound in Medicine & Biology·X A VerbeekA P Hoeks
May 10, 2001·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·T BernatikD Becker
Aug 21, 2001·The British Journal of Radiology·N BangJ F Pedersen
Oct 26, 2002·Journal of Hepatology·Hiroyuki SugimotoAkimasa Nakao
Jul 17, 2003·Gut·M J K BlomleyS D Taylor-Robinson
Jun 16, 2004·European Journal of Gastroenterology & Hepatology·Thomas BernatikDeike Strobel
Dec 14, 2004·Gut·A K P LimM J K Blomley
Apr 23, 2005·The British Journal of Radiology·X ZhouT Bernatik
Jan 19, 2006·World Journal of Gastroenterology : WJG·Rong-Qin ZhengYasuhiro Sakaguchi
May 25, 2006·Radiology·Adrian K P LimMartin J K Blomley
Dec 21, 2006·European Radiology·Tommaso Vincenzo BartolottaRoberto Lagalla
Aug 3, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F RidolfiE Brunelli
Dec 12, 2007·The British Journal of Radiology·J H ZhouF Han
Citations
Apr 7, 2011·Radiology·Xiang ZhouMeng Zhu
Jun 22, 2011·Clinics in Liver Disease·Nedim Hadzic, Milton J Finegold
Mar 10, 2015·Ultrasound in Medicine & Biology·Yan FengXiang Zhou
Sep 4, 2019·BMC Medical Imaging·Xin-Pei ChenSong Su
Aug 20, 2018·Abdominal Radiology·Wei ZhuBin Song