Characterization of folate-graft-chitosan as a scaffold for nitric oxide release

International Journal of Biological Macromolecules
Ajun WanHuili Li

Abstract

The preparation and characterization of nitric oxide (NO)-releasing chitosan-folate conjugates were reported. The secondary amine chitosan-folate conjugates exhibited a high storage capacity for NO (up to 84.3 nmol NO/mg) (when the graft rate of folate was 12.5%), greatly increasing the "payload" of released NO with the graft rate of folate increasing. The NO release durations (12h) observed for secondary amine the chitosan-folate conjugates with the high graft rate (12.5%) were largerly shorter compared to O2-protected diazeniumliolates with BrCH2CH3 (24 h), thus illustrating a macromolecular effect on NO release kinetics.

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Citations

Apr 5, 2011·Journal of Materials Science. Materials in Medicine·Yu-long Tan, Chen-Guang Liu
Nov 26, 2013·Biomaterials·Yuan LuMark H Schoenfisch
Jul 28, 2016·International Journal of Biological Macromolecules·Sameh H OthmanAhmed M Elbarbary
Aug 10, 2018·Toxicology Research·Muhammad Farhan SohailGul Shahnaz
May 23, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yong TianLingyi Sun
May 7, 2011·Bioconjugate Chemistry·Alice GalbiatiAlessandro Desideri
Oct 30, 2021·ACS Applied Materials & Interfaces·Yun QianElizabeth J Brisbois

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