PMID: 6402858Jan 1, 1983Paper

Characterization of formaldehyde-related antibodies encountered in hemodialysis patients at different stages of immunization

Vox Sanguinis
R LynenE Gallasch

Abstract

In hemodialysis patients who reuse formaldehyde-sterilized dialysers we found that antibodies agglutinating native NN red cells belonged exclusively to the IgM fraction of immunoglobulins. In the same patients antibodies directed against formaldehyde-altered NN red cells proved to be mainly IgG in addition to IgM. Three stages of formaldehyde-dependent RBC immunization could be distinguished serologically. The production of these antibodies was dependent on the time of hemodialysis treatment. We found antibodies which could bind complement in the presence of soluble antigen. These antibodies are supposed to damage the patient's red cells immediately after contact to minute amounts of formaldehyde during hemodialysis.

References

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Citations

Aug 1, 1984·Toxicology and Applied Pharmacology·H K LeeM H Karol
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·H GarpenstrandU Rosenqvist
Jan 1, 1984·Journal of Toxicology and Environmental Health·J R Beall, A G Ulsamer
Dec 1, 1984·Environmental Health Perspectives
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Paramjit KaurBankim Das
Jun 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R VanholderS Ringoir
Dec 1, 1985·Kidney International·R M HakimE G Lowrie
Apr 1, 1989·Toxicology and Applied Pharmacology·P L Goering
Oct 1, 1992·Regulatory Toxicology and Pharmacology : RTP·C C Chang, M E Gershwin
Jul 19, 2013·Seminars in Dialysis·Angela D Coulliette, Matthew J Arduino
Nov 6, 2004·Renal Failure·Henrique E M FonsecaJosé Orlando Bordin

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