Characterization of Four Nearly Full-Length Genomic Sequences of HIV-1 Subtype G Identified in Guangdong Province, China

AIDS Research and Human Retroviruses
Tianyi LiLin Li

Abstract

Four cases infected by HIV-1 subtype G strain were identified in Guangdong, China. The nearly full-length genome was amplified and sequenced for phylogenetic analysis. The four sequences clustered together with subtype G references in the tree (bootstrap value ≥98%). To determine whether HIV-1 subtype G has been spreading in China, all subtype G sequences identified in China were downloaded from HIV Database for further phylogenetic analysis. In the phylogenetic tree of pol gene (nucleotides 2283-3245 by using HXB2 as a calibrator), four clusters with bootstrap value >70% comprised nine sequences from China were identified, suggesting that subtype G might have been spreading in local areas in China. The detailed sequence data in this study will provide more information on HIV epidemic in China. The result also highlighted that more surveillance on subtype G prevalence in China is necessary.

References

Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Jun 10, 2010·AIDS Research and Human Retroviruses·Lin LiJingyun Li
Feb 8, 2011·AIDS·Joris HemelaarUNKNOWN WHO-UNAIDS Network for HIV Isolation and Characterisation
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jul 21, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marcel TongoJeffrey R Dorfman
Jul 31, 2016·AIDS Research and Human Retroviruses·Awatef El MoussiAmine Slim

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Citations

Apr 18, 2020·The Journal of Antimicrobial Chemotherapy·Yun LanFengyu Hu

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Methods Mentioned

BETA
RNA

Software Mentioned

ATGC
MEGA
BioEdit
Clustal ×
PhyML
COMET

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