Characterization of frequency-dependent material properties of human liver and its pathologies using an impact hammer

Medical Image Analysis
M Umut OzcanYaman Tokat

Abstract

The current methods for characterization of frequency-dependent material properties of human liver are very limited. In fact, there is almost no data available in the literature showing the variation in dynamic elastic modulus of healthy or diseased human liver as a function of excitation frequency. We show that frequency-dependent dynamic material properties of a whole human liver can be easily and efficiently characterized by an impact hammer. The procedure only involves a light impact force applied to the tested liver by a hand-held hammer. The results of our experiments conducted with 15 human livers harvested from the patients having some form of liver disease show that the proposed approach can successfully differentiate the level of fibrosis in human liver. We found that the storage moduli of the livers having no fibrosis (F0) and that of the cirrhotic livers (F4) varied from 10 to 20 kPa and 20 to 50 kPa for the frequency range of 0-80 Hz, respectively.

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Citations

Apr 30, 2013·Journal of Biomechanics·Z Ilke KalciogluKrystyn J Van Vliet
Jun 27, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Costin D Untaroiu, Yuan-Chiao Lu
Apr 14, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Aldo Leal-EgañaJosef Käs
Apr 11, 2014·Journal of Magnetic Resonance Imaging : JMRI·Sohae ChungLeon Axel
Jun 5, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Mehmet AyyildizCagatay Basdogan
Jul 30, 2014·Biomedical Optics Express·Tony J AklGerard L Coté
Sep 14, 2011·Acta Biomaterialia·Timothy D SargeantJoshua B Stopek
Nov 5, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Berkay YarpuzluCagatay Basdogan
Sep 8, 2017·Journal of Biomedical Materials Research. Part a·Vince BeachleyJennifer Elisseeff

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