Characterization of Gadolinium Contrast Enhancement of Radiofrequency Ablation Lesions in Predicting Edema and Chronic Lesion Size

Circulation. Arrhythmia and Electrophysiology
Elyar GhafooriRavi Ranjan

Abstract

Magnetic resonance imaging (MRI) has been used to acutely visualize radiofrequency ablation lesions, but its accuracy in predicting chronic lesion size is unknown. The main goal of this study was to characterize different areas of enhancement in late gadolinium enhancement MRI done immediately after ablation to predict acute edema and chronic lesion size. In a canine model (n=10), ventricular radiofrequency lesions were created using ThermoCool SmartTouch (Biosense Webster) catheter. All animals underwent MRI (late gadolinium enhancement and T2-weighted edema imaging) immediately after ablation and after 1, 2, 4, and 8 weeks. Edema, microvascular obstruction, and enhanced volumes were identified in MRI and normalized to chronic histological volume. Immediately after contrast administration, the microvascular obstruction region was 3.2±1.1 times larger than the chronic lesion volume in acute MRI. Even 60 minutes after contrast administration, edema was 8.7±3.31 times and the enhanced area 6.14±2.74 times the chronic lesion volume. Exponential fit to the microvascular obstruction volume was found to be the best predictor of chronic lesion volume at 26.14 minutes (95% prediction interval, 24.35-28.11 minutes) after contrast inject...Continue Reading

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Citations

Jan 5, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Antonio Berruezo, Ingo Paetsch
Jun 24, 2018·Pacing and Clinical Electrophysiology : PACE·Basar CandemirCetin Erol
Aug 15, 2018·Journal of Cardiovascular Electrophysiology·Eugene G KholmovskiRavi Ranjan
Oct 29, 2017·Circulation. Arrhythmia and Electrophysiology·Timothy M Markman, Saman Nazarian
Oct 31, 2018·Journal of Cardiovascular Electrophysiology·Kennosuke YamashitaRavi Ranjan
Feb 13, 2019·Circulation. Arrhythmia and Electrophysiology·Wendy S TzouSuraj Kapa
Mar 28, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Rahul K MukherjeeMark D O'Neill
Oct 1, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael A GuttmanAravindan Kolandaivelu
Sep 11, 2019·Current Cardiovascular Imaging Reports·Rahul K MukherjeeMark D O'Neill
Feb 14, 2020·Pacing and Clinical Electrophysiology : PACE·Rama VunnamTimm Dickfeld
Feb 23, 2020·JACC. Clinical Electrophysiology·Kennosuke YamashitaRavi Ranjan
Nov 30, 2020·JACC. Cardiovascular Imaging·Timm Dickfeld, Rama Vunnam
May 27, 2020·Cardiac Electrophysiology Clinics·Mohammadali HabibiHugh Calkins
May 7, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Aravindan KolandaiveluDaniel A Herzka
Jan 23, 2022·Journal of Cardiovascular Electrophysiology·Majd A El-Harasis, Travis D Richardson

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