PMID: 3763045Aug 29, 1986Paper

Characterization of gamma-aminobutyric acid responses with sulfate loading in cat bladder neurons

Neuroscience Letters
M NohmiJ P Gallagher

Abstract

In some cells in cat bladder ganglia gamma-aminobutyric acid (GABA) applied iontophoretically produced a hyperpolarizing response accompanied by an increase in input conductance when recorded with potassium sulfate-filled microelectrodes. This GABA-induced hyperpolarization was blocked by bicuculline and was converted to a depolarizing GABA response when extracellular chloride concentration was low suggesting that the hyperpolarizing GABA response was mediated by the opening of chloride channels. In other cells, continuous passage of a small negative current converted a depolarizing GABA response to a hyperpolarizing response with time. This effect was accompanied by a negative shift of the reversal potential. These data indicated that injection of impermeable sulfate ions decreased the intracellular chloride concentration.

References

Jan 1, 1985·The Journal of Physiology·D A Brown, A A Selyanko
Oct 5, 1981·Brain Research·M L MayerJ P Gallagher

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Citations

May 1, 1990·Pflügers Archiv : European journal of physiology·E Kumamoto, P Shinnick-Gallagher
Sep 1, 1988·Journal of the Autonomic Nervous System·T TokimasaT Akasu

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