PMID: 9431925Feb 12, 1998Paper

Characterization of gentamicin-susceptible strains of methicillin-resistant Staphylococcus aureus involved in nosocomial spread

Journal of Clinical Microbiology
Nadine LemaitreV Jarlier

Abstract

We report an outbreak of epidemic Staphylococcus aureus strains characterized by an unusual heterogeneous resistance to methicillin and resistance to tobramycin but susceptibility to gentamicin (gentamicin-susceptible methicillin-resistant S. aureus [GS-MRSA]), contrasting with gentamicin-resistant homogeneous MRSA (GR-MRSA) that have been endemic in our hospital since the 1970s. A total of 97 GS-MRSA strains, which were shown by DNA hybridization to carry the mecA and ant(4')-Ia genes, were studied. The 40 GS-MRSA strains isolated at the beginning of the outbreak (January 1992 to June 1993) were typed by using resistance patterns, phage typing, serotyping, and pulsed-field gel electrophoresis and were compared with GR-MRSA and methicillin-susceptible S. aureus (MSSA) strains isolated during the same period. Two dominant clones, A::1 and B::3, and one minor clone, C::5, were identified among the 40 GS-MRSA strains, according to pulsotypes (A to C) and their resistance patterns (1, 3, and 5), which were distinguishable from those of GR-MRSA and MSSA strains. A selection of 57 GS-MRSA strains, isolated from 1994 to 1996, were clustered in the same three clones. However, their distribution had changed in comparison with that in th...Continue Reading

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Citations

Dec 13, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I ChmelnitskyY Carmeli
Oct 1, 2015·Environmental Monitoring and Assessment·Akebe Luther King AbiaMaggy Ndombo Benteke Momba
Aug 22, 2007·Antimicrobial Agents and Chemotherapy·Pierre-Yves DonnioAlain Le Coustumier
Aug 4, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·UNKNOWN Hôpital Propre II Study Group
Jul 29, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jérôme RobertVincent Jarlier
Jul 20, 2019·Colloids and Surfaces. B, Biointerfaces·Alejandra Rodríguez-ContrerasElisa Ruperez
Feb 15, 2002·Veterinary Microbiology·Janaína dos Santos NascimentoMaria do Carmo de Freire Bastos
Dec 8, 2004·Journal of Clinical Microbiology·Nathalie van der Mee-MarquetUNKNOWN Bloodstream Infection Study Group of the Relais d'Hygiène du Centre
Mar 30, 2002·Journal of Clinical Microbiology·Claudia SolaUNKNOWN Córdoba MRSA Collaborative Study Group

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