Nov 16, 2019

Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli

BMC Nephrology
Flavia Teodora Ioana PaunasBjørn Egil Vikse


IgA nephropathy (IgAN) involves mesangial matrix expansion, but the proteomic composition of this matrix is unknown. The present study aimed to characterize changes in extracellular matrix in IgAN. In the present study we used mass spectrometry-based proteomics in order to quantitatively compare protein abundance between glomeruli of patients with IgAN (n = 25) and controls with normal biopsy findings (n = 15). Using a previously published paper by Lennon et al. and cross-referencing with the Matrisome database we identified 179 extracellular matrix proteins. In the comparison between IgAN and controls, IgAN glomeruli showed significantly higher abundance of extracellular matrix structural proteins (e.g periostin, vitronectin, and extracellular matrix protein 1) and extracellular matrix associated proteins (e.g. azurocidin, myeloperoxidase, neutrophil elastase, matrix metalloproteinase-9 and matrix metalloproteinase 2). Periostin (fold change 3.3) and azurocidin (3.0) had the strongest fold change between IgAN and controls; periostin was also higher in IgAN patients who progressed to ESRD as compared to patients who did not. IgAN is associated with widespread changes of the glomerular extracellular matrix proteome. Proteins imp...Continue Reading

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Mentioned in this Paper

Biological Markers
Increased Mesangial Matrix
Cell Injury
Extracellular Matrix
IGA Glomerulonephritis
Glomerulosclerosis (Disorder)
Viral Structural Proteins
Matrix Metalloproteinase 9

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