Characterization of HCV structural proteins expressed in various animal cells

Intervirology
Y MatsuuraT Miyamura

Abstract

Hepatitis C virus (HCV) is a main causative agent for transfusion-associated and sporadic cases of non-A, non-B hepatitis throughout the world. HCV has a positive-strand RNA of about 9,400 nucleotides as its genome, whose organization is similar to those of animal pestiviruses or human flaviviruses. In spite of the lack of an effective replication system in tissue culture cells, genes coding for viral proteins of HCV have been identified. The putative nucleocapsid (p22) and envelope (gp35 and gp60) proteins have been expressed in cells by different vectors under various foreign promoters. Furthermore, a truncated core protein and association of envelope proteins with nonstructural proteins have also been observed. These synthesized viral proteins have been shown to be useful for diagnostic assays.

Citations

Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Song Hee LeeSung Key Jang
Apr 16, 2009·Reviews in Medical Virology·Chad D Williamson, Anamaris M Colberg-Poley
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A RullierB Le Bail
Oct 19, 2011·International Journal of Hepatology·Alessia BianchiMarcello Merola

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