Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis

Nephrology
Richard HolmanPaolo Ferrari

Abstract

Parenteral iron is integral in the treatment of anaemia of chronic kidney disease patients on haemodialysis (HD). However, increased liver iron concentration (LIC) can result from such treatment, and this correlates poorly with serum ferritin or transferrin saturation values. It is unclear whether increased cardiac iron concentration also occurs in this setting. We aimed to evaluate the relationship of intravenous iron supplementation to hepatic and cardiac iron deposition in chronic HD subjects. A cohort of 10 patients on chronic HD for at least 1 year underwent MRI-based quantitation of hepatic and cardiac iron content to evaluate the relationship between intravenous iron supplements and hepatic and cardiac iron deposition. The results were compared against the cumulative parenteral iron dose and serum iron markers. The median age was 61 years (95% confidence interval (CI) 50-71), HD time 2.5 years (95%CI 2.0-5.3) and cumulative iron dose 4300 mg (95%CI 2110-9045). Hepatic iron concentration was elevated in eight of 10 subjects (median 46 mmol/kg, range 31-76). Cardiac iron levels were within the reference range in all subjects. There was poor correlation between conventional haematinic values and either LIC or cardiac iron l...Continue Reading

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Citations

Mar 23, 2017·Hemodialysis International·Ganesh RamanathanPaolo Ferrari
Feb 14, 2018·American Journal of Nephrology·Jay B WishJohn C Wood
Mar 16, 2018·Current Opinion in Cardiology·Carles Díez-LópezJosé González-Costello
Mar 3, 2018·Current Cardiovascular Imaging Reports·Kenneth MangionElaine Rutherford
Feb 11, 2021·Clinical Kidney Journal·Takeshi Nakanishi, Takahiro Kuragano
Feb 1, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Aleix CasesUNKNOWN en representación del Grupo de Anemia de la S.E.N.
Jun 1, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Aleix CasesUNKNOWN en representación del Grupode Anemia de la S.E.N.

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