Characterization of hepatitis B and delta coinfection in Israel

BMC Infectious Diseases
Rachel ShiraziOrna Mor

Abstract

Characteristics of hepatitis B (HBV) and delta (HDV) coinfection in various geographical regions, including Israel, remain unclear. Here we studied HDV seroprevalence in Israel, assessed HDV/HBV viral loads, circulating genotypes and hepatitis delta antigen (HDAg) conservation. Serological anti HDV IgG results from 8969 HBsAg positive individuals tested in 2010-2015 were retrospectively analyzed to determine HDV seroprevalence. In a cohort of HBV/HDV coinfected (n=58) and HBV monoinfected (n=27) patients, quantitative real-time PCR (qRT-PCR) and sequencing were performed to determine viral loads, genotypes and hepatitis delta antigen (HDAg) protein sequence. 6.5% (587/8969) of the HBsAg positive patients were positive for anti HDV antibodies. HDV viral load was >2 log copies/ml higher than HBV viral load in most of the coinfected patients with detectable HDV RNA (86%, 50/58). HDV genotype 1 was identified in all patients, most of whom did not express HBV. While 66.6% (4/6) of the HBV/HDV co-expressing patients carried HBV-D2 only 18.5% (5/27) of the HBV monoinfections had HBV-D2 (p=0.03). Higher genetic variability in the HDAg protein sequence was associated with higher HDV viral load. The overall significant prevalence of HDV ...Continue Reading

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Citations

Feb 6, 2020·Clinical Liver Disease·Murat AkyıldızCihan Yurdaydın
Jan 24, 2021·Journal of Hepatology·Mario RizzettoFranco Negro

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Datasets Mentioned

BETA
X04451
AB674436

Methods Mentioned

BETA
ELISA
genotyping
PCR

Software Mentioned

Expasy
- gene
Open
Clustal
Open system
LOGO
Mega

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