PMID: 9525592Apr 3, 1998Paper

Characterization of hepatitis G virus (GB-C virus) particles: evidence for a nucleocapsid and expression of sequences upstream of the E1 protein

Journal of Virology
J XiangJ T Stapleton

Abstract

Hepatitis G virus (HGV or GB-C virus) is a newly described virus that is closely related to hepatitis C virus (HCV). Based on sequence analysis and by evaluation of translational initiation codon preferences utilized during in vitro translation, HGV appears to have a truncated or absent core protein at the amino terminus of the HGV polyprotein. Consequently, the biophysical properties of HGV may be very different from those of HCV. To characterize HGV particle types, we evaluated plasma from chronically infected individuals with and without concomitant HCV infection by using sucrose gradient centrifugation, isopycnic banding in cesium chloride, and saline density flotation centrifugation. Similar to HCV, HGV particles included an extremely-low-density virion particle (1.07 to 1.09 g/ml) and a nucleocapsid of approximately 1.18 g/ml. One major difference between the particle types was that HGV was consistently more stable in cesium chloride than HCV. Plasma samples from chronically HGV-infected individuals and controls were assessed by a synthetic peptide-based immunoassay to determine if they contained HGV antibody specific for a conserved region in the coding region upstream of the E1 protein. Chronically HGV-infected individu...Continue Reading

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Citations

Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W N SchmidtD L Brashear
Mar 5, 2004·The New England Journal of Medicine·Carolyn F WilliamsJack T Stapleton
May 6, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jinhua XiangJack T Stapleton
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nina F RoseJohn K Rose
Mar 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jack T Stapleton, Kathryn Chaloner
Sep 18, 2009·Journal of Viral Hepatitis·Emma L Mohr, Jack T Stapleton
Oct 16, 2016·Annual Review of Virology·Alex S HartlageAmit Kapoor
Apr 12, 2000·Journal of Viral Hepatitis·J XiangJ T Stapleton
Nov 4, 2000·Journal of Gastroenterology and Hepatology·T KandaH Saisho
Aug 23, 2008·World Journal of Gastroenterology : WJG·Vasiliy Ivanovich ReshetnyakLjudmila Urievna Ilchenko
Feb 11, 2005·Current Gastroenterology Reports·Sarah L George, Dino Varmaz
May 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nirjal BhattaraiJack T Stapleton
Sep 8, 2001·The New England Journal of Medicine·J XiangJ T Stapleton
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael G Hughes, Hugo R Rosen
Mar 1, 2014·Emerging Microbes & Infections·Stephanie PfaenderEike Steinmann
Nov 16, 2002·Current Infectious Disease Reports·Sarah L. GeorgeJack T. Stapleton
Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Giovana Lotici Baggio-Zappia, Celso Francisco Hernandes Granato
Jul 28, 2019·Journal of Medical Virology·Takuma IzumiTomoharu Yoshizumi
Jan 31, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Daniele LapaAnna Rosa Garbuglia
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Haiying WangShixing Tang

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