Nov 2, 2019

Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation

Hippocampus
Robin de FloresLaura E M Wisse

Abstract

Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark band, a hypointense layer visible in T2-weighted MRI. Our main findings are that: (a) there is a consistent order of appearance of subfields in the hippocampal head, (b) the composition of subfields i...Continue Reading

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Mentioned in this Paper

Uncus of Hippocampus
Coronal
In Vivo
Middle Region of Body
Research
Magnetic Resonance Imaging
Anatomic Structures
Anatomical Space Structure
Description
Aging

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