PMID: 7522047Jul 1, 1994Paper

Characterization of homogeneously staining regions in a small cell lung cancer cell line, using in situ hybridization with an MYCN probe

Genes, Chromosomes & Cancer
E DietzschO M Garson

Abstract

The cell line CIPL38 was derived from the pleural effusion of a patient with small cell lung cancer. The karyotype was hyperdiploid and complex with a variable number of marker chromosomes. Two of the markers had large homogeneously staining regions (hsr), which were shown to consist of amplified MYCN by in situ hybridization. One hsr bearing a marker chromosome could not be identified with G-banding, but the other was situated on a der(14). This was elucidated further with FISH analysis, which enabled the identification of sequences of chromosome i involved in a complex rearrangement with chromosome 14 and the hsr.

References

Jan 1, 1990·Genes, Chromosomes & Cancer·M Schwab, L C Amler
Sep 1, 1989·Cancer Genetics and Cytogenetics·G M Brodeur, C T Fong
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C EscotR Callahan
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Citations

May 14, 2003·Cancer Genetics and Cytogenetics·Estela PedrazziniIrma Slavutsky
Mar 12, 2004·Cancer Letters·Manfred Schwab
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·J C Alers, H van Dekken
Jan 18, 2014·Clinical & Experimental Ophthalmology·Brigitte L ThériaultTimothy W Corson

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