Characterization of human D-amino acid oxidase

FEBS Letters
Gianluca MollaLoredano Polegioni

Abstract

D-Amino acid oxidase (DAAO) has been proposed to be involved in the oxidation of D-serine, an allosteric activator of the NMDA-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia. The recombinant human DAAO was expressed in Escherichia coli and was isolated as an active homodimeric flavoenzyme. It shows the properties of the dehydrogenase-oxidase class of flavoproteins, possesses a low kinetic efficiency, and follows a ternary complex (sequential) kinetic mechanism. In contrast to the other known DAAOs, the human enzyme is a stable homodimer even in the apoprotein form and weakly binds the cofactor in the free form.

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Citations

Feb 2, 2013·Applied Microbiology and Biotechnology·Davide BifulcoGianluca Molla
Aug 7, 2012·Amino Acids·Silvia SacchiGianluca Molla
Sep 30, 2009·Molecular Psychiatry·L VerrallP J Harrison
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jumpei SasabeSadakazu Aiso
May 19, 2007·Antioxidants & Redox Signaling·Patrick J HalveyDean P Jones
Oct 3, 2012·Neurology Research International·John P CrowMisty Thompson
Jul 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sumiko IwasaTakeshi Fukushima
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trisha L KalbaughJeffrey S Diamond
Jul 18, 2014·Bioscience Trends·Miho ShishikuraTakeshi Fukushima
Mar 3, 2010·Cellular and Molecular Life Sciences : CMLS·Loredano Pollegioni, Silvia Sacchi
Aug 26, 2010·Protein Expression and Purification·Chunyang ZhengZhiguo Su
Jun 6, 2009·Protein Expression and Purification·Diego RomanoFlavia Marinelli
Feb 17, 2007·Biochemical and Biophysical Research Communications·Tomoya KawazoeKiyoshi Fukui
Dec 5, 2006·The FEBS Journal·Masumi KataneHiroshi Homma
Sep 8, 2010·Journal of Neuroendocrinology·A YamamotoK Horiike
Jun 4, 2010·Protein Science : a Publication of the Protein Society·Laura CaldinelliLoredano Pollegioni
Jun 17, 2011·Brain Research·Sabine A FuchsTom J de Koning
Apr 15, 2015·Journal of Pharmaceutical and Biomedical Analysis·Francesco ErricoAlessandro Usiello
Oct 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camilo RojasBarbara S Slusher
Oct 25, 2012·Neuroscience and Biobehavioral Reviews·Eva DrewsAndreas Zimmer
Jun 18, 2011·Molecular and Cellular Neurosciences·Silvia SacchiLoredano Pollegioni
Jul 9, 2014·Bioscience Reports·Ryan T Terry-LorenzoThomas H Large
Feb 24, 2015·Biochimica Et Biophysica Acta·Pamela CappellettiSilvia Sacchi
Dec 12, 2012·Biochimica Et Biophysica Acta·Laura CaldinelliLoredano Pollegioni
Feb 16, 2012·Protein Expression and Purification·Elena TallaritaGianluca Molla
May 14, 2014·Frontiers in Synaptic Neuroscience·Jill F BettsPaul J Harrison
Oct 22, 2014·Amino Acids·Marialaura MarchettiAndrea Mozzarelli
Dec 22, 2015·Chemical & Pharmaceutical Bulletin·Shohei ToguchiToshiaki Sunazuka
Aug 25, 2015·Journal of Biomolecular Screening·Ryan T Terry-LorenzoLoredano Pollegioni
Feb 7, 2017·FEBS Letters·Silvia SacchiLoredano Pollegioni
Jan 13, 2018·Frontiers in Molecular Biosciences·Giulia MurtasLoredano Pollegioni

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