Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles

Tissue Antigens
G BertrandJ Coste

Abstract

The low-affinity Fc gamma receptor IIIb (Fc gamma RIIIb and CD16b) is constituted by a unique FCGR3B polypeptide chain that comprises two extracellular immunoglobulin-like domains, and is expressed as a glycosylphosphatidyl inositol-anchored receptor on the neutrophils. The FCGR3B chain bears allotypes that define the human neutrophil antigen-1 (HNA-1 and NA) system involved in major post-transfusional reactions. FCGR3B is highly homologous to FCGR3A, which is expressed as a transmembrane receptor on natural killer cells and monocytes/macrophages. Its transcription products were not yet fully characterized. In the present work, we sequenced FCGR3B cDNAs with complete 3' untranslated region from purified granulocytes of HNA-1b/HNA-1b (NA2/NA2) genotyped donors. We characterized two FCGR3B cDNAs of different lengths corresponding to two polyadenylation sites. This result was corroborated by data raised by serial analysis of gene expression (SAGE). FCGR3B allele polymorphisms, from this article [FCGR3B*02 (HNA-1b, NA2)] and from the literature, are described for the first time according to the IMGT standardized nomenclature and to the IMGT unique numbering for C-LIKE-DOMAIN (http://imgt.cines.fr). These rules, described in the IMG...Continue Reading

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Citations

Dec 3, 2014·Hematology/oncology Clinics of North America·Elizabeth Kang, Andrew Gennery
Apr 5, 2013·Genes and Immunity·K HaldorsenA I Bolstad
Mar 27, 2009·Vox Sanguinis·K S BlumB K Flesch
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Dec 2, 2004·Developmental and Comparative Immunology·Marie-Paule LefrancGérard Lefranc
Jun 7, 2005·Developmental and Comparative Immunology·Marie-Paule LefrancGérard Lefranc
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc

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