PMID: 6406805Jan 1, 1983Paper

Characterization of human interferon-gamma-producing leukocytes with monoclonal antileukocyte antibodies

Medical Microbiology and Immunology
J AbbF Deinhardt

Abstract

Monoclonal antibodies with specificities for subsets of human leukocytes have been used for the characterization of interferon (IFN) gamma-producing cells. The production of IFN gamma was demonstrated to be a function of OKT3+T lymphocytes. The capacity to secrete IFN gamma was not restricted to the OKT4+ or the OKT8+T-cell subset. BA-1+B lymphocytes and Leu7+ natural killer cells did not contribute to the production of IFN gamma. Ia+, OKM1+ monocytes served an auxiliary function in the production of IFN gamma. The requirement for accessory monocytes, however, was not absolute, because monocyte-free preparations of long-term cultured IL2-dependent T lymphocytes retained the capacity to secrete IFN gamma.

References

Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Feb 9, 1972·Nature: New Biology·T G KawakamiR V Gilden
Aug 1, 1982·Immunopharmacology·J AbbF Deinhardt

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Citations

Jun 1, 1986·European Journal of Clinical Microbiology·J AbbF Deinhardt
Jul 1, 1997·Journal of the Neurological Sciences·K P WandingerH Kirchner
Jun 1, 1984·Experimental Cell Research·I SchoberH Kirchner
Aug 25, 2006·Clinical and Vaccine Immunology : CVI·Evelyn HartmannBarbara Wollenberg
Dec 15, 2004·Journal of Virology·Kelli McKennaNina Bhardwaj
Aug 1, 1988·Annals of Neurology·U Traugott, P Lebon

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