Characterization of human-like menstruation in the spiny mouse: comparative studies with the human and induced mouse model

Human Reproduction
Nadia BellofioreJemma Evans

Abstract

Is the newly discovered menstruating rodent, the spiny mouse, a valid model for studying endometrial morphology and menstruation? Our study is the first to demonstrate a primate-like pattern of natural menstruation in a rodent, with decidualization, spiral arteriole remodeling and piece-meal endometrial shedding. The spiny mouse has a naturally occurring menstrual cycle. This unique feature has the potential to reduce the heavy reliance on primates and provide a more appropriate small animal model for menstrual physiology research. This study compares morphological changes in the endometrium during early, mid and late menstruation of the spiny mouse (n = 39), human (n = 9) and the induced mouse model of menstruation (n = 17). We assessed tissue morphology with hematoxylin and eosin and erythrocyte patterns with Mallory's trichrome. We conducted staining for neutrophil gelatinase associated lipocalin (NGAL), cytokeratin and interleukin-11 (IL-11) in all species. We used double immunofluorescence staining for vascular endothelial growth factor and alpha-smooth muscle actin to detect vasculature remodeling and western immunoblot to detect interleukin-8 (IL-8) and macrophage migration inhibitory factor (MIF) in the menstrual fluid ...Continue Reading

References

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Aug 10, 2016·American Journal of Obstetrics and Gynecology·Nadia BellofioreHayley Dickinson

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Citations

Feb 8, 2020·Physiological Reviews·Hilary O D CritchleyAlistair R W Williams
Feb 27, 2020·Development·Malcolm Maden, Justin A Varholick
Jan 6, 2019·Journal of Assisted Reproduction and Genetics·Nadia Bellofiore, Jemma Evans
Nov 12, 2020·Seminars in Reproductive Medicine·Caitlin E FilbyCaroline E Gargett
Jan 6, 2021·Laboratory animal research·Fitriya N Dewi, J Mark Cline
Jan 23, 2021·Journal of Clinical Medicine·Hiromi MurataHidetaka Okada
Mar 7, 2021·Scientific Reports·Jarrod McKennaPeter Temple-Smith
Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Phoebe M KirkwoodPhilippa T K Saunders
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Roman EremichevPavel Makarevich
Aug 28, 2021·Journal of Personalized Medicine·Manako YamaguchiTakayuki Enomoto
Oct 4, 2021·Human Reproduction·Nadia BellofiorePeter Temple-Smith

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