PMID: 321366Apr 15, 1977Paper

Characterization of human lymphocyte subpopulations for cytotoxicity against tumor-derived monolayer cultures

International Journal of Cancer. Journal International Du Cancer
T BakacsE Klein

Abstract

Lymphocyte fractions of three healthy donors were tested for cytotoxicity in a 48-h assay on several tumor-derived lines. Analysis of surface markers indicated that a non-T non-B fraction comprising about 50% Fc-receptor-positive cells was most potent. The cell yield in this fraction was on the average 6.5% of the non-fractionated population. Elimination of Slg positive cells did not influence the cytotoxic potential. Pure T cells isolated with E-rosetting subsequent to passage on nylon wool column had no or very low low cytotoxicity. We had indications that cells without conventional markers--"null" cells--were also cytotoxic.

References

Jul 15, 1975·International Journal of Cancer. Journal International Du Cancer·P HerseyD S Nelson
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E Svedmyr, M Jondal
Mar 15, 1977·International Journal of Cancer. Journal International Du Cancer·M TakasugiA Ramseyer
Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·M Jondal, H Pross
Mar 1, 1976·Journal of the National Cancer Institute·M Kiuchi, M Takasugi
Jul 1, 1972·The Journal of Experimental Medicine·H B Dickler, H G Kunkel
Oct 15, 1974·International Journal of Cancer. Journal International Du Cancer·J E de VriesP Rumke
Jan 1, 1973·International Archives of Allergy and Applied Immunology·T HallbergR R Coombs
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Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen

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Citations

Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M G MasucciW Berthold
Aug 1, 1979·Australian and New Zealand Journal of Medicine·P Hersey
Jan 1, 1979·Immunological Reviews·R B HerbermanP Puccetti
Apr 1, 1978·Cancer Letters·T BakacsK G Ljungström
Mar 15, 1981·Cellular Immunology·D S RobbinsA J Strelkauskas
Nov 1, 1977·European Journal of Immunology·B M VoseE Klein
Mar 15, 1981·International Journal of Cancer. Journal International Du Cancer·M Moore, B M Vose
Nov 15, 1978·International Journal of Cancer. Journal International Du Cancer·Y KoideM Takasugi
May 1, 1990·Clinical and Experimental Immunology·J A Tratkiewicz, J Szer
May 15, 1978·International Journal of Cancer. Journal International Du Cancer·R L VessellaM E Kaplan
Aug 1, 1986·Cellular Immunology·N GengozianR A Good

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