Characterization of hydroxyl radical generation in the striatum of free-moving rats due to carbon monoxide poisoning, as determined by in vivo microdialysis

Brain Research
Shuichi HaraTakahiko Endo

Abstract

Carbon monoxide (CO) poisoning caused by CO exposure at 3000 ppm for 40 min resulted in stimulation of hydroxyl radical (*OH) generation (estimated by measuring 2,3-dihydroxybenzoic acid (2,3-DHBA) production from salicylic acid) in the striatum of free-moving rats, as determined by means of brain microdialysis. Pretreatment with a voltage-dependent Na+ channel blocker, tetrodotoxin (TTX), lowered the basal level of 2,3-DHBA and strongly suppressed the increase in 2,3-DHBA induced by CO poisoning. CO poisoning significantly, though only slightly, increased extracellular glutamate in the striatum, and glutamate (Glu) receptor antagonists, such as MK-801 (dizocilpine) and NBQX, failed to suppress the CO-induced increase in 2,3-DHBA. These findings suggest that CO poisoning may induce Na+ influx via the voltage-dependent Na+ channels, resulting in stimulation of *OH generation in rat striatum. This effect may be independent of Glu receptor activation by increased extracellular Glu.

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Citations

Apr 28, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nele Plock, Charlotte Kloft
Jan 25, 2012·Free Radical Biology & Medicine·Shuichi HaraHajime Mizukami
Mar 30, 2010·Medical Hypotheses·Meihua ShenZhenglu Huo
Apr 24, 2013·CNS Neuroscience & Therapeutics·Mei-Hua ShenXue Jun Sun
Apr 30, 2014·Redox Report : Communications in Free Radical Research·Sumeyya AkyolOmer Akyol
Dec 7, 2010·Biochemical and Biophysical Research Communications·Yong-Peng YuJing-Hua Shao
Sep 23, 2016·Journal of the Neurological Sciences·Meihua ShenJianfeng Gong
Apr 17, 2021·Journal of Pharmacological Sciences·Fumi KuriiwaShuichi Hara

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