Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2

Microbes and Infection
Lei FuAnding Zhang

Abstract

IgA1 protease of Streptococcus suis serotype 2 (SS2) has been proven to be relative with virulence and immunogenicity, however, its protective efficacy remained to be evaluated. The present study found evidence that immunization with purified recombinant IgA1 protease (600-1926aa) could induce high IgG antibody titers and could confer complete protection against a challenge with a lethal dose of SS2 in a mouse model. In addition, our findings confirmed that the IgA1 protease distributes on the surface of SS2. Therefore, the present study identified the virulence-associated protein, IgA1 protease, as a novel surface protective antigen of SS2.

References

Apr 9, 2005·Clinical and Diagnostic Laboratory Immunology·Ogi Okwumabua, Sharmila Chinnapapakkagari
Apr 6, 2006·PLoS Medicine·Jiaqi TangGeorge F Gao
Jun 15, 2007·Clinical and Vaccine Immunology : CVI·Yuanyi LiJosee Harel
Nov 20, 2008·The Journal of Infectious Diseases·Mariela Segura
Jul 22, 2009·Veterinary Microbiology·Anding ZhangMeilin Jin
Jul 27, 2010·Journal of Proteomics·Francesca MandaniciManuel J Rodríguez-Ortega
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Jun 25, 2014·Future Microbiology·Mariela SeguraMarcelo Gottschalk
Jun 25, 2014·Emerging Infectious Diseases·Vu Thi Lan HuongKenji Hirayama

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