Characterization of IgE-mediated cutaneous immediate and late-phase reactions in nonallergic horses

American Journal of Veterinary Research
Michelle C WoodwardCherie M Pucheu-Haston


To characterize the response of skin of nonallergic horses following ID injection of polyclonal rabbit anti-canine IgE (anti-IgE) and rabbit IgG. 6 healthy horses. Skin in the cervical area was injected ID with anti-IgE and IgG. Wheal measurements and skin biopsy specimens were obtained before and 20 minutes and 6, 24, and 48 hours after injection. Tissue sections were evaluated for inflammatory cells at 4 dermal depths. Immunohistochemical analysis for CD3, CD4, and CD8 was performed, and cell counts were evaluated. Anti-IgE wheals were significantly larger than IgG wheals at 20 minutes and 6 and 24 hours after injection. There were significantly more degranulated mast cells after anti-IgE injection than after IgG injection. There were significantly more eosinophils at 6, 24, and 48 hours and neutrophils at 6 hours after anti-IgE injection, compared with cell numbers at those same times after IgG injection. There were significantly more eosinophils in the deeper dermis of anti-IgE samples, compared with results for IgG samples. No significant differences between treatments were detected for CD3(+), CD4(+), or CD8(+) cells. Injection of anti-IgE antibodies was associated with the development of gross and microscopic inflammatio...Continue Reading


Jul 1, 1991·Equine Veterinary Journal·S Halldórdsóttir, H J Larsen
Jul 1, 1990·Equine Veterinary Journal·V A Fadok, E C Greiner
Jan 1, 1985·Allergy·R Grönneberg, O Zetterström
Mar 1, 1985·Clinical Allergy·R Grönneberg, O Zetterström
May 28, 1983·The Veterinary Record·Y BravermanP J Quinn
Jan 1, 1995·Veterinary Immunology and Immunopathology·A P FosterF M Cunningham
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·E N Charlesworth
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Mar 30, 2001·American Journal of Veterinary Research·G LorchE Jose-Cunilleras
Jan 5, 2002·Equine Veterinary Journal·A van der HaegenE Marti
Jul 10, 2002·Veterinary Pathology·V K Affolter, P F Moore
Mar 12, 2003·Veterinary Immunology and Immunopathology·Bettina WagnerWolfgang Leibold
Apr 22, 2005·Veterinary Dermatology·Silvia RüfenachtPetra J Roosje
Oct 13, 2005·The FEBS Journal·Stephen F AltschulYi-Kuo Yu
Sep 16, 2006·Veterinary Research·Bettina WagnerDouglas F Antczak
Sep 22, 2006·Acta Veterinaria Scandinavica·Sigrídur BjörnsdóttirAgúst Sigurdsson
Oct 20, 2009·Veterinary Immunology and Immunopathology·Bettina WagnerDouglas F Antczak

❮ Previous
Next ❯


Aug 16, 2014·Veterinary Dermatology·Thomas Bieber

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.