Characterization of imaging performance in differential phase contrast CT compared with the conventional CT: spectrum of noise equivalent quanta NEQ(k)

Medical Physics
Xiangyang TangShaojie Tang

Abstract

Differential phase contrast CT (DPC-CT) is emerging as a new technology to improve the contrast sensitivity of conventional attenuation-based CT. The noise equivalent quanta as a function over spatial frequency, i.e., the spectrum of noise equivalent quanta NEQ(k), is a decisive indicator of the signal and noise transfer properties of an imaging system. In this work, we derive the functional form of NEQ(k) in DPC-CT. Via system modeling, analysis, and computer simulation, we evaluate and verify the derived NEQ(k) and compare it with that of the conventional attenuation-based CT. The DPC-CT is implemented with x-ray tube and gratings. The x-ray propagation and data acquisition are modeled and simulated through Fresnel and Fourier analysis. A monochromatic x-ray source (30 keV) is assumed to exclude any system imperfection and interference caused by scatter and beam hardening, while a 360° full scan is carried out in data acquisition to avoid any weighting scheme that may disrupt noise randomness. Adequate upsampling is implemented to simulate the x-ray beam's propagation through the gratings G(1) and G(2) with periods 8 and 4 μm, respectively, while the intergrating distance is 193.6 mm (1∕16 of the Talbot distance). The dimensi...Continue Reading

References

Mar 1, 1979·Medical Physics·R F WagnerM S Pastel
Sep 1, 1979·Medical Physics·K M Hanson
May 1, 1978·Physics in Medicine and Biology·S J RiedererD A Chesler
Oct 1, 1976·Computers in Biology and Medicine·H H BarrettR S Hershel
Jan 1, 1988·Physics in Medicine and Biology·E L Nickoloff
Jul 1, 1995·Medical Physics·C E MetzK J Myers
Apr 1, 1995·Medical Physics·A Momose, J Fukuda
Dec 5, 2002·Medical Physics·J H SiewerdsenD A Jaffray
Oct 9, 2004·Physics in Medicine and Biology·Frédéric NooJed D Pack
Sep 2, 2005·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Adolf W LohmannJürgen Jahns
Apr 17, 2009·Physics in Medicine and Biology·Martin BechF Pfeiffer
Feb 24, 2010·Medical Physics·Cheng-Ying Chou, Mark A Anastasio
Mar 16, 2011·Physics in Medicine and Biology·Rainer Raupach, Thomas G Flohr
Jun 2, 2011·Medical Physics·Jongduk Baek, Norbert J Pelc
Jul 1, 2011·Medical Physics·Thomas KöhlerEwald Roessl
Jun 1, 1985·Physics in Medicine and Biology·Robert F Wagner, David G Brown

Citations

Nov 6, 2015·Radiation Protection Dosimetry·A H ClavelA Darbon
Aug 6, 2013·Physics in Medicine and Biology·Ge Wang, Hengyong Yu
Apr 26, 2014·Journal of Synchrotron Radiation·Silvia PeterMarco Stampanoni
Oct 9, 2014·Physics in Medicine and Biology·Srinivasan VedanthamAndrew Karellas
May 2, 2015·Journal of Synchrotron Radiation·Yuan BaoZiyu Wu
Oct 13, 2020·Journal of X-ray Science and Technology·Aimin YanHong Liu

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.