Characterization of imaging performance in differential phase contrast CT compared with the conventional CT: spectrum of noise equivalent quanta NEQ(k)

Medical Physics
Xiangyang TangShaojie Tang


Differential phase contrast CT (DPC-CT) is emerging as a new technology to improve the contrast sensitivity of conventional attenuation-based CT. The noise equivalent quanta as a function over spatial frequency, i.e., the spectrum of noise equivalent quanta NEQ(k), is a decisive indicator of the signal and noise transfer properties of an imaging system. In this work, we derive the functional form of NEQ(k) in DPC-CT. Via system modeling, analysis, and computer simulation, we evaluate and verify the derived NEQ(k) and compare it with that of the conventional attenuation-based CT. The DPC-CT is implemented with x-ray tube and gratings. The x-ray propagation and data acquisition are modeled and simulated through Fresnel and Fourier analysis. A monochromatic x-ray source (30 keV) is assumed to exclude any system imperfection and interference caused by scatter and beam hardening, while a 360° full scan is carried out in data acquisition to avoid any weighting scheme that may disrupt noise randomness. Adequate upsampling is implemented to simulate the x-ray beam's propagation through the gratings G(1) and G(2) with periods 8 and 4 μm, respectively, while the intergrating distance is 193.6 mm (1∕16 of the Talbot distance). The dimensi...Continue Reading


Mar 1, 1979·Medical Physics·R F WagnerM S Pastel
Sep 1, 1979·Medical Physics·K M Hanson
May 1, 1978·Physics in Medicine and Biology·S J RiedererD A Chesler
Oct 1, 1976·Computers in Biology and Medicine·H H BarrettR S Hershel
Jan 1, 1988·Physics in Medicine and Biology·E L Nickoloff
Jul 1, 1995·Medical Physics·C E MetzK J Myers
Apr 1, 1995·Medical Physics·A Momose, J Fukuda
Dec 5, 2002·Medical Physics·J H SiewerdsenD A Jaffray
Oct 9, 2004·Physics in Medicine and Biology·Frédéric NooJed D Pack
Sep 2, 2005·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Adolf W LohmannJürgen Jahns
Apr 17, 2009·Physics in Medicine and Biology·Martin BechF Pfeiffer
Feb 24, 2010·Medical Physics·Cheng-Ying Chou, Mark A Anastasio
Mar 16, 2011·Physics in Medicine and Biology·Rainer Raupach, Thomas G Flohr
Jun 2, 2011·Medical Physics·Jongduk Baek, Norbert J Pelc
Jul 1, 2011·Medical Physics·Thomas KöhlerEwald Roessl
Jun 1, 1985·Physics in Medicine and Biology·Robert F Wagner, David G Brown


Nov 6, 2015·Radiation Protection Dosimetry·A H ClavelA Darbon
Aug 6, 2013·Physics in Medicine and Biology·Ge Wang, Hengyong Yu
Apr 26, 2014·Journal of Synchrotron Radiation·Silvia PeterMarco Stampanoni
Oct 9, 2014·Physics in Medicine and Biology·Srinivasan VedanthamAndrew Karellas
May 2, 2015·Journal of Synchrotron Radiation·Yuan BaoZiyu Wu
Oct 13, 2020·Journal of X-ray Science and Technology·Aimin YanHong Liu

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