Characterization of immune cells and cytokine localization in the rat utero-placental unit mid- to late gestation

Journal of Reproductive Immunology
Daniel R TessierAndrée Gruslin

Abstract

The success of pregnancy is dependent on the precise regulation of the immune response within the utero-placental environment. Rats are beginning to be widely used as a model for human immune-related pregnancy complications. However, our knowledge of immune cells and cytokine localization in the rat utero-placental tissue is limited. The current study aimed to localize the immune cell populations, including uterine natural killer (uNK) cells, neutrophils, and macrophages within the rat utero-placental unit at two crucial gestational ages, gestational days 15.5 and 18.5. In addition, we characterized the distribution of the cytokines TNFα, IFNγ, and IL-10 in the utero-placental regions at both the above-mentioned gestational ages. Our study has demonstrated co-localization TNFα and IFNγ with uNK cells in perivascular regions of the rat mesometrial triangle at both gestational ages. Neutrophils and IL-10-positive cells were localized at the maternal-fetal interface and in the spiral artery lumen of the rat mesometrial triangle at both gestational ages. TNFα and IL-10 demonstrated a temporal change in the localization from GD15.5 to GD18.5, which coincides with the leading edge of trophoblast invasion into the mesometrial triangle...Continue Reading

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Citations

Mar 5, 2016·Cell Adhesion & Migration·Stavros GiaglisSinuhe Hahn
Nov 21, 2017·Reproductive Sciences·Kanchan VaswaniMurray D Mitchell
Jan 10, 2019·American Journal of Reproductive Immunology : AJRI·Jorge LimaMaria Leandro
Oct 15, 2019·International Reviews of Immunology·Sulagna DuttaNazmul Haque
Apr 6, 2020·Cellular and Molecular Life Sciences : CMLS·Linda GroenewegNoelia A-Gonzalez
Apr 23, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Olivia K TravisDenise C Cornelius

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