Characterization of immunoglobulin gamma 1 from a monotreme, Tachyglossus aculeatus

Immunogenetics
Katherine BelovDesmond W Cooper

Abstract

A full-length immunoglobulin gamma clone from the echidna (Tachyglossus aculeatus) was isolated from a spleen cDNA library. The clone was 1,664 base pairs long and encoded the entire open reading frame, incorporating the V, D, J and C regions. The echidna clone had approximately 41% identity and 67% similarity at the amino acid level with both marsupial and eutherian IgG molecules. The presence of IgG in the monotremes confirms that the appearance of IgG occurred prior to the separation of the three extant mammalian lineages, but after their separation from the reptilian lineage, pinpointing the date to between 310 and 170 million years ago. Phylogenetic analyses using the immunoglobulin sequence data strongly support the 'Theria' hypothesis, with the monotreme lineage diverging prior to the separation of the marsupial and eutherian lineages.

Citations

Sep 28, 2004·Immunogenetics·Melissa A NowakRobert D Miller
Oct 16, 2002·Developmental and Comparative Immunology·Katherine BelovDesmond W Cooper
Jul 25, 2003·Molecular Phylogenetics and Evolution·Matthew J Phillips, David Penny
Dec 12, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Katherine Belov, Lars Hellman
Dec 12, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A M Musser
Mar 20, 2012·Developmental and Comparative Immunology·Francisco Gambón-DezaSusana Magadán-Mompó
Mar 1, 2012·Developmental and Comparative Immunology·Yi SunYaofeng Zhao
Jun 10, 2009·Molecular Immunology·F Gambón-DezaS Magadán-Mompó
Nov 9, 2004·Current Opinion in Genetics & Development·Frank Grützner, Jennifer A Marshall Graves
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaofeng ZhaoLennart Hammarström

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