Characterization of in vivo Achilles tendon forces in rabbits during treadmill locomotion at varying speeds and inclinations

Journal of Biomechanics
John R WestDavid L Butler

Abstract

The objective of this study was to test the hypothesis that increasing the speed and inclination of the treadmill increases the peak Achilles tendon forces and their rates of rise and fall in force. Implantable force transducers (IFT) were inserted in the confluence of the medial and lateral heads of the left gastrocnemius tendon in 11 rabbits. IFT voltages were successfully recorded in 8 animals as the animals hopped on a treadmill at each of two speeds (0.1 and 0.3 mph) and inclinations (0 degrees and 12 degrees). Instrumented tendons were isolated shortly after sacrifice and calibrated. Contralateral unoperated tendons were failed in uniaxial tension to determine maximum or failure force, from which safety factor (ratio of maximum force to peak in vivo force) was calculated for each activity. Peak force and the rates of rise and fall in force significantly increased with increasing treadmill inclination (p<0.001). Safety factors averaged 30.8+/-7.5 for quiet standing, 7.0+/-2.9 for level hopping, and 5.2+/-0.7 for inclined hopping (mean+/-SEM). These in vivo force parameters will help tissue engineers better design functional tissue engineered constructs for rabbit Achilles tendon and other tendon repairs. Force patterns can...Continue Reading

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Citations

Mar 27, 2007·Annals of Biomedical Engineering·Krishna R AsundiDavid M Rempel
May 6, 2006·Tissue Engineering·Natalia Juncosa-MelvinDavid L Butler
Aug 12, 2009·Tissue Engineering. Part B, Reviews·Kathleen A DerwinJesse A McCarron
Jul 1, 2009·Integrative and Comparative Biology·Emanuel AziziThomas J Roberts
Dec 11, 2007·Journal of Biomechanical Engineering·Victor S NirmalanandhanDavid L Butler
Feb 2, 2011·Journal of Biomechanical Engineering·Safa T HerfatDavid L Butler
Jan 6, 2009·American Journal of Veterinary Research·Stephanie A ListerJames K Roush
Nov 10, 2013·Journal of Biomechanics·Andrew P BreidenbachDavid L Butler
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Michael J Bey, Kathleen A Derwin
Mar 14, 2007·Journal of Biomechanics·Dustin M GroverScott J Hazelwood
Feb 3, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stavros ThomopoulosKathleen A Derwin
Feb 10, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kirsten R C KinnebergDavid L Butler
Dec 18, 2012·Biotechnology and Bioengineering·Tao WangMing H Zheng
Jun 12, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Etienne John Ogilvy O'BrienDavid A Hart
Aug 18, 2009·Journal of Tissue Engineering and Regenerative Medicine·Hallie E BrinkSteven B Nicoll
Aug 27, 2005·Journal of Biomechanics·M R DresslerG P Boivin
May 17, 2017·The Journal of Bone and Joint Surgery. American Volume·Shivam A ShahStavros Thomopoulos
May 19, 2017·Biomechanics and Modeling in Mechanobiology·M AlipourJ Fernandez
Mar 21, 2018·Connective Tissue Research·Arash MehdizadehDavid W Smith
Aug 7, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·David L ButlerHani Awad
Feb 8, 2006·Clinical Orthopaedics and Related Research·James H-C WangFreddie H Fu
Feb 5, 2015·Annals of Biomedical Engineering·Anthony RatcliffeEvan L Flatow
Jun 25, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nathaniel A DymentDavid L Butler
Mar 1, 2013·Journal of Biomechanical Engineering·David L ButlerChristopher Wylie
Aug 18, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michelle WallAlbert J Banes
Jan 30, 2020·Current Stem Cell Research & Therapy·Wang HengJohn H Barker
Jun 3, 2021·Sensors·Melissa M SuckeyJeffrey N Anker

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